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SLC12A5 / KCC2
solute carrier family 12 (potassium/chloride transporter), member 5
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.
| Gene Name: | solute carrier family 12 (potassium/chloride transporter), member 5 |
| Family/Subfamily: | Transporter , Cation:chloride symporter |
| Synonyms: | SLC12A5, Erythroid K-Cl cotransporter 2, HKCC2, K-Cl cotransporter 2, KCC2, KIAA1176, Neuronal K-Cl cotransporter |
| Target Sequences: | NM_020708 NP_065759.1 Q9H2X9 |
Publications (1)
1
Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy. Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ. EBioMedicine. 2018 June;32:62-71. (Mouse)
[Full Text Article]
[PubMed:29884458]
[PMC:PMC6020795]
Related Antibodies: LS-C135150.
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SLC12A5 / KCC2 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
SLC12A5 / KCC2 Mouse anti-Human Monoclonal (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
100 µg/$442
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (Biotin) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
Biotin Conjugated
100 µg/$475
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (FITC) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
FITC Conjugated
100 µg/$472
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (APC) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
APC Conjugated
100 µg/$478
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (PerCP) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
PerCP Conjugated
100 µg/$478
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (RPE) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
RPE Conjugated
100 µg/$477
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (Atto 390) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
Atto 390 Conjugated
100 µg/$479
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (Atto 488) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
Atto 488 Conjugated
100 µg/$479
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (Atto 594) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
Atto 594 Conjugated
100 µg/$479
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
SLC12A5 / KCC2 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$832
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal (aa5-33) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SLC12A5 / KCC2 Mouse anti-Rat Monoclonal (aa932-1043) (S1-12) Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
100 µg/$665
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SLC12A5 / KCC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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