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SLC12A4 / KCC1
solute carrier family 12 (potassium/chloride transporter), member 4
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl- exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
| Gene Name: | solute carrier family 12 (potassium/chloride transporter), member 4 |
| Family/Subfamily: | Transporter , Cation:chloride symporter |
| Synonyms: | SLC12A4, Erythroid K-Cl cotransporter 1, HKCC1, KCC1, K-Cl cotransporter, Erythroid K:Cl cotransporter |
| Target Sequences: | NM_005072 NP_005063.1 Q9UP95 |
Publications (1)
1
The Zn(2+)-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl(-) absorption, via basolateral KCC1, and reduces fluid loss. Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M. Biochimica et biophysica acta. 2017 1863:947-960. (WB; Human)
[Full Text Article]
[PubMed:28093242]
[PMC:PMC5557417]
Related Antibodies: LS-B2377.
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Products
ELISA Kits
(1)
Type
Sandwich
(1)
Target
SLC12A4 / KCC1
(1)
Reactivity
Rat
(1)
Format
96-Well Strip Plate
(1)
Publications
No
(1)
Sample Type
Cell Lysates
(1)
Tissue Homogenates
(1)
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$783
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