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SLC12A1 / NKCC2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A1 / NKCC2 is a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
| Gene Name: | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 |
| Family/Subfamily: | Transporter , Cation:chloride symporter |
| Synonyms: | SLC12A1, BSC1, MBSC1, Na-K-2Cl cotransporter, NKCC2A variant A, RBSC, NKCC2 |
| Target Sequences: | NM_000338 NP_000329.2 Q13621 |
Publications (2)
1
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Human molecular genetics. 2015 24:4545-58. (WB; Human)
[Full Text Article]
[PubMed:25994507]
[PMC:PMC4512625]
Related Antibodies: LS-C313275.
2
Whole-exome resequencing reveals recessive mutations in TRAP1 in individuals with CAKUT and VACTERL association. Saisawat P, Kohl S, Hilger AC, Hwang DY, Yung Gee H, Dworschak GC, Tasic V, Pennimpede T, Natarajan S, Sperry E, Matassa DS, Staji[Character 107] N, Bogdanovic R, de Blaauw I, Marcelis CL, Wijers CH, Bartels E, Schmiedeke E, Schmidt D, M[Character e4]rzheuser S, Grasshoff-Derr S, Holland-Cunz S, Ludwig M, N[Character f6]then MM, Draaken M, Brosens E, Heij H, Tibboel D, Herrmann BG, Solomon BD, de Klein A, van Rooij IA, Esposito F, Reutter HM, Hildebrandt F. Kidney international. 2014 Jun;85:1310-7. [Full Text Article]
[PubMed:24152966]
[PMC:PMC3997628]
Related Antibodies: LS-C150446.
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SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa125-139) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa351-400) Antibody
Human
IHC, WB
Unconjugated
100 µl/$424
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa351-400) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, WB
HRP Conjugated
100 µl/$469
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa351-400) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, WB
Biotin Conjugated
100 µl/$469
SLC12A1 / NKCC2 Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$449
SLC12A1 / NKCC2 Rabbit anti-Rat Polyclonal (aa33-55) (FITC) Antibody
Mouse, Rat, Human
WB
FITC Conjugated
100 µg/$480
SLC12A1 / NKCC2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, IHC, IHC-Pfa, WB
Unconjugated
100 µg/$832
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa52-83) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SLC12A1 / NKCC2 Mouse anti-Human Monoclonal (4H4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
SLC12A1 / NKCC2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$801
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$832
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Rat, Human
WB
HRP Conjugated
100 µl/$1,054
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
WB
Biotin Conjugated
100 µl/$1,054
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Rat, Human
WB
FITC Conjugated
100 µl/$1,054
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Rat, Human
WB
APC Conjugated
100 µl/$1,054
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Rat, Human
WB
PE Conjugated
100 µl/$1,054
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa814-1099) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa814-1099) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa814-1099) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal (aa814-1099) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
SLC12A1 / NKCC2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
SLC12A1 / NKCC2 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$632
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product results
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