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SLC11A2 / DMT1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
Solute carrier family 11, member 2 (SLCA2) also known as divalent metal ion transporter 1 (DMT1) imports Fe2+ via a proton-coupled, membrane potential dependent manner. It can also transport a variety of other divalent metal cations including Mn2+, Co2+, Cu2+, and Zn2+ but iron appears to be its most important physiological substrate. SLC11A2 has been demonstrated on the apical membrane of duodenal enterocytes, transferrin cycle endosomes in erythroid precursors, hepatocytes where it has been postulated to be involved in non-transferrin-bound iron uptake, and placenta where it has been implicated in transfer of iron from mother to fetus.
| Gene Name: | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
| Family/Subfamily: | Transporter , Natural resistance-associated macrophage protein (NRAMP) |
| Synonyms: | SLC11A2, Divalent metal transporter 1, Divalent cation transporter 1, DMT-1, NRAMP 2, NRAMP2, Dct-1, DCT1, DMT1 |
| Target Sequences: | NM_000617 NP_000608.1 P49281 |
Publications (1)
1
Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines. Straud S, Zubovych I, De Brabander JK, Roth MG. PloS one. 2010 5:e11629. (WB; Human)
[Full Text Article]
[PubMed:20661293]
[PMC:PMC2905441]
Related Antibodies: LS-C16687.
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Fast Shipping
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
SLC11A2 / DMT1 Mouse anti-Human Monoclonal (4C6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
SLC11A2 / DMT1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$832
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) Antibody
Mouse
IF, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$832
SLC11A2 / DMT1 Rabbit anti-Rat Polyclonal (4th Cytoplasmic Domain) Antibody
Rat
ELISA, IHC, WB
Unconjugated
100 µg/$832
SLC11A2 / DMT1 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$379
SLC11A2 / DMT1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$832
SLC11A2 / DMT1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µl/$801
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$801
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$783
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
200 µl/$734
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IF, WB
Biotin Conjugated
200 µl/$952
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) (FITC) Antibody
Mouse, Human
ELISA, ICC, IF, WB
FITC Conjugated
200 µl/$952
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) (APC) Antibody
Mouse, Human
ELISA, ICC, IF, WB
APC Conjugated
200 µl/$952
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) (PE) Antibody
Mouse, Human
ELISA, ICC, IF, WB
PE Conjugated
200 µl/$952
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal (aa262-291) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
SLC11A2 / DMT1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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