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High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Gene Name: | signaling lymphocytic activation molecule family member 1 |
Synonyms: | SLAMF1, CD150 antigen, CD150, IPO-3, SLAM, CDw150 |
Target Sequences: | NM_003037 NP_003028.1 Q13291 |
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