SKP2

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

SKP2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

SKP2 (8)

Publications

No (8)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human SKP2 Protein (Recombinant 6His-SUMO, N-terminus) (Full Length) - LS-G21651

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

63.73 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human SKP2 Protein (Recombinant GST) (Full Length) - LS-G30419

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SKP2 Protein (Recombinant GST, N-terminus) (aa176-285) - LS-G60101

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SKP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81526

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.6 kDa

Price:

20 µg/$215

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Human SKP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68136

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.6 kDa

Price:

20 µg/$1,107

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SKP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100699

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.6 kDa

Price:

100 µg/$710

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Human SKP2 Protein (Recombinant His, N-Terminal) - LS-G144338

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

47.6 kDa

Price:

50 µg/$419

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Human SKP2 Protein (Recombinant His-T7) (aa43-397) - LS-G25130

Source:

E. coli

Tag:

His-T7

Molecular Weight:

43.7 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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