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SIRT4 / Sirtuin 4
sirtuin 4
Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
| Gene Name: | sirtuin 4 |
| Family/Subfamily: | ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase |
| Synonyms: | SIRT4, Sir2-like 4, SIR2-like protein 4, Sirtuin 4, Sirtuin type 4, SIR2L4 |
| Target Sequences: | NM_012240 NP_036372.1 Q9Y6E7 |
Publications (1)
1
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis. Kai Su Greene, Michael J Lukey, Xueying Wang, Bryant Blank, Joseph E Druso, Miao-Chong J Lin, Clint A Stalnecker, Chengliang Zhang, Yashira Negrón Abril, Jon W Erickson, Kristin F Wilson, Hening Lin, Robert S Weiss, Richard A Cerione. Proceedings of the National Academy of Sciences of the United States of America. 2019 December; [Full Text Article]
[PubMed:31843902]
[PMC:PMC6936584]
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SIRT4 / Sirtuin 4 Goat anti-Human Polyclonal (aa302-314) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) (HRP) Antibody
Dog, Pig, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) (Biotin) Antibody
Dog, Pig, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa216-265) (FITC) Antibody
Dog, Pig, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SIRT4 / Sirtuin 4 Mouse anti-Human Monoclonal (aa1-50) Antibody
Human
ELISA
Unconjugated
150 µg/$842
SIRT4 / Sirtuin 4 Chicken anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$460
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
SIRT4 / Sirtuin 4 Mouse anti-Human Monoclonal (6G6D2) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
SIRT4 / Sirtuin 4 Mouse anti-Human Monoclonal (6A12D7) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa67-95) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
IP, WB
Unconjugated, Preservative Free
20 µl/$256; 100 µl/$412
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SIRT4 / Sirtuin 4 Rabbit anti-Mouse Polyclonal (aa26-333) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
WB
Unconjugated
100 µl/$424
SIRT4 / Sirtuin 4 Rabbit anti-Human Polyclonal (aa36-85) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
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