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SIRT3 / Sirtuin 3

sirtuin 3

SIRT3 / Sirtuin 3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene.

Gene Name: sirtuin 3
Family/Subfamily: ADP-Ribosyltransferase , not assigned-ADP-Ribosyltransferase
Synonyms: SIRT3, HSIRT3, Sir2-like 3, SIR2-like protein 3, SIR2L3, Sirtuin 3, Sirtuin type 3
Target Sequences: NM_012239 NP_036371.1 Q9NTG7

Publications (2)

1
FoxO1 mediates an autofeedback loop regulating SIRT1 expression. Xiong S, Salazar G, Patrushev N, Alexander RW. The Journal of biological chemistry. 2011 286:5289-99. [PubMed:21149440] [PMC:PMC3037641] Related Antibodies: LS-C100489.
2
Integration of -catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. Parker JA, Vazquez-Manrique RP, Tourette C, Farina F, Offner N, Mukhopadhyay A, Orfila AM, Darbois A, Menet S, Tissenbaum HA, Neri C. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:12630-40. [PubMed:22956852] Related Antibodies: LS-C100489.

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Proteins (12)
Over-Expression Lysate (4)
Recombinant (8)
SIRT3 / Sirtuin 3 (12)
No (12)
GST (1)
GST, N-terminus (1)
His (3)
His, N-Terminal (2)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (6)
Mouse (2)
Rat (2)
293T Cells (2)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
SIRT3 / Sirtuin 3 Protein
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E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
SIRT3 / Sirtuin 3 Protein - Recombinant  Sirtuin 3 By SDS-PAGE
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E. coli
His
30.1 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
SIRT3 / Sirtuin 3 Protein
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E. coli
His-T7
32.3 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
SIRT3 / Sirtuin 3 Protein - 12.5% SDS-PAGE of human SIRT3 stained with Coomassie Blue
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Wheat Germ Extract
GST
69.63 kDa
2 µg/$439
SIRT3 / Sirtuin 3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
29 kDa
20 µg/$150
SIRT3 / Sirtuin 3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
43.4 kDa
20 µg/$150
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HEK 293 Cells
Myc-DDK (Flag)
29 kDa
100 µg/$494
SIRT3 / Sirtuin 3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
43.4 kDa
100 µg/$494
SIRT3 / Sirtuin 3 Protein - Active Sirtuin 3 (SIRT3) by WB
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E. coli
His, N-Terminal
16&29kDa
10 µg/$329; 50 µg/$740; 200 µg/$1,349; 100 µg/$1,141; 1 mg/$2,628; 500 µg/$2,123; 5 mg/$5,167; 2 mg/$2,818
SIRT3 / Sirtuin 3 Protein - Recombinant Sirtuin 3 By SDS-PAGE
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E. coli
His
21.1 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
SIRT3 / Sirtuin 3 Protein - Active Sirtuin 3 (SIRT3) by WB
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E. coli
His, N-Terminal
22kDa
10 µg/$337; 50 µg/$790; 200 µg/$1,414; 100 µg/$1,200; 1 mg/$2,709; 500 µg/$2,204; 5 mg/$5,517; 2 mg/$2,943
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).