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SIRPA / CD172a

signal-regulatory protein alpha

CD172A / SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Gene Name: signal-regulatory protein alpha
Synonyms: SIRPA, CD172A, CD172a antigen, Inhibitory receptors shps-1, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, p84, SHPS-1, SHPS1, SIRP, Sirp-alpha-1, Sirp-alpha-3, Sirp-alpha1, MYD1, SIRPalpha, SIRPalpha2, BIT, MFR, MYD-1, PTPNS1, SHP substrate 1, Sirp-alpha-2, CD172
Target Sequences: NM_080792 NP_542970.1 P78324

Publications (1)

1
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Yifan Yuan, Katherine L Leiby, Allison M Greaney, Micha Sam Brickman Raredon, Hong Qian, Jonas C Schupp, Alexander J Engler, Pavlina Baevova, Taylor S Adams, Mehmet H Kural, Juan Wang, Tomohiro Obata, Mervin C Yoder, Naftali Kaminski, Laura E Niklason. Frontiers in bioengineering and biotechnology. 2021 December;9:760309. [Full Text Article] [PubMed:34869270] [PMC:PMC8640093] Related Antibodies: LS-B551.

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ELISA Kits (9)
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SIRPA / CD172a (9)
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SIRPA / CD172a ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
SIRPA / CD172a ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SIRPA / CD172a ELISA Kit
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Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SIRPA / CD172a ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
SIRPA / CD172a ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SIRPA / CD172a ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$581
SIRPA / CD172a ELISA Kit
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Custom
96-Well Strip Plate
Human
1 Plate/$669
SIRPA / CD172a ELISA Kit
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Custom
96-Well Strip Plate
Rat
1 Plate/$669
SIRPA / CD172a ELISA Kit
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Custom
96-Well Strip Plate
Bovine
1 Plate/$669
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).