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SIRPA / CD172a
signal-regulatory protein alpha
CD172A / SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
| Gene Name: | signal-regulatory protein alpha |
| Synonyms: | SIRPA, CD172A, CD172a antigen, Inhibitory receptors shps-1, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MyD-1 antigen, p84, SHPS-1, SHPS1, SIRP, Sirp-alpha-1, Sirp-alpha-3, Sirp-alpha1, MYD1, SIRPalpha, SIRPalpha2, BIT, MFR, MYD-1, PTPNS1, SHP substrate 1, Sirp-alpha-2, CD172 |
| Target Sequences: | NM_080792 NP_542970.1 P78324 |
Publications (1)
1
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Yifan Yuan, Katherine L Leiby, Allison M Greaney, Micha Sam Brickman Raredon, Hong Qian, Jonas C Schupp, Alexander J Engler, Pavlina Baevova, Taylor S Adams, Mehmet H Kural, Juan Wang, Tomohiro Obata, Mervin C Yoder, Naftali Kaminski, Laura E Niklason. Frontiers in bioengineering and biotechnology. 2021 December;9:760309. [Full Text Article]
[PubMed:34869270]
[PMC:PMC8640093]
Related Antibodies: LS-B551.
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SIRPA / CD172a Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
SIRPA / CD172a Mouse anti-Human Monoclonal (aa1-370) (03) Antibody
Human
ELISA, IHC-P
Unconjugated
50 µl/$460
SIRPA / CD172a Rabbit anti-Human Polyclonal (aa451-500) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
SIRPA / CD172a Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
ICC, IF, IP, WB
Unconjugated
100 µl/$299
SIRPA / CD172a Mouse anti-Human Monoclonal (OTI7B3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
SIRPA / CD172a Mouse anti-Pig Monoclonal (BL1H7) Antibody
Pig
Flo, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.1 mg/$402
SIRPA / CD172a Rabbit anti-Human Polyclonal (aa31-373) Antibody
Human
ELISA, IF, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SIRPA / CD172a Rabbit anti-Human Polyclonal (aa31-373) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
SIRPA / CD172a Mouse anti-Human Monoclonal (OTI1H1) Antibody
Human
WB
Unconjugated
100 µl/$434
SIRPA / CD172a Mouse anti-Human Monoclonal (OTI1B5) Antibody
Human
WB
Unconjugated
100 µl/$434
SIRPA / CD172a Mouse anti-Human Monoclonal (Carrier-free) (OTI1B5) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$501
SIRPA / CD172a Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$505
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SIRPA / CD172a Mouse anti-Human Monoclonal (2H7E2) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
SIRPA / CD172a Rabbit anti-Mouse Monoclonal (APC) (012) Antibody
Mouse
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$421
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
SIRPA / CD172a Mouse anti-Human Monoclonal (1C6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SIRPA / CD172a Rabbit anti-Mouse Monoclonal (PE) (001) Antibody
Mouse
Flo
PE Conjugated
25 Tests/$278; 100 Tests/$376
SIRPA / CD172a Rabbit anti-Human Polyclonal (aa105-324) (APC, Cy7) Antibody
Pig, Human
WB
APC, Cy7 Conjugated
100 µl/$476; 200 µl/$590; 500 µl/$1,069; 1 ml/$1,265; 2 ml/$1,771; 5 ml/$3,319
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Fast Shipping
SIRPA / CD172a Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
SIRPA / CD172a Mouse anti-Rat Monoclonal (OX-41) Antibody
Rat
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
1 mg/$712
SIRPA / CD172a Mouse anti-Rat Monoclonal (Biotin) Antibody
Rat
Flo, IHC, IHC-Fr, IHC-P
Biotin Conjugated
100 µg/$688
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