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SIPA1
signal-induced proliferation-associated 1
Sipa 1 (signal-induced proliferation associated gene 1) is a mitogen-induced GTPase activating protein. It exhibits specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. Sipa1 may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. Sipa 1 has been found in the nucleus, cytoplasm and perinuclear regions, but most in the perinuclear membranous region. The same isoform is encoded by two splice variants.
| Gene Name: | signal-induced proliferation-associated 1 |
| Synonyms: | SIPA1, Sipa-1, SPA1, p130 SPA-1 |
| Target Sequences: | NM_006747 NP_006738.3 Q96FS4 |
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