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Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Gene Name: | salt-inducible kinase 2 |
Family/Subfamily: | Protein Kinase , CAMKL |
Synonyms: | SIK2, KIAA0781, LOH11CR1I, SNF1LK2, QIK, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, SNF1-like kinase 2 |
Target Sequences: | AB018324 BAA34501.3 Q9H0K1 |
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