SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

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Products

Antibodies (44)

Proteins (19)

Type

Over-Expression Lysate (6)

Primary (44)

Recombinant (13)

Target

SIGIRR (63)

Reactivity

Human (26)

Mouse (20)

Rat (13)

Bovine (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Pig (8)

Zebrafish (3)

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Application

IHC (10)

IHC-Fr (2)

IHC-P (7)

WB (37)

Flo (3)

ELISA (5)

Host

rabbit (43)

mouse (1)

Product Group

IHCPlus (1)

Isotype

IgG (13)

IgG2a (1)

Clonality

monoclonal mc (1)

polyclonal pc (43)

Format

APC (3)

APC Conjugated (4)

Biotin Conjugated (5)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (5)

Preservative Free (1)

Unconjugated (14)

Epitope

aa1-118 (16)

aa1-117 (8)

C-Terminus (6)

aa334-358 (1)

Publications

No (63)

Tag

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

Fc (1)

GST (1)

His (3)

His-Fc (1)

His-GST (1)

Human IgG1 Fc, C-terminus (1)

Myc-DDK (Flag) (9)

Species

Human (11)

Mouse (4)

Rat (1)

Source

293T Cells (3)

E. coli (4)

HEK 293 Cells (7)

Human Cells (3)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (4)

Select

SIGIRR Antibody (APC) LS-C132109

Antibody:

SIGIRR Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

APC Conjugated

Price:

100 Tests/$930

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SIGIRR Antibody (PE) LS-C489280

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

Flo

Format:

PE Conjugated

Price:

25 Tests/$293; 100 Tests/$376

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SIGIRR Antibody (C-Terminus) LS-B5817

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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SIGIRR Antibody (C-Terminus, HRP) LS-C452473

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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SIGIRR Antibody (C-Terminus, Biotin) LS-C452676

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SIGIRR Antibody (C-Terminus, FITC) LS-C452472

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SIGIRR Antibody (aa1-117) LS-C296440

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (aa1-117) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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SIGIRR Antibody (aa1-117, FITC) LS-C696600

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (aa1-117) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$366; 200 µl/$432; 500 µl/$683; 1 ml/$842; 2 ml/$1,088; 5 ml/$1,941

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SIGIRR Antibody (aa1-117, Cy3) LS-C705581

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (aa1-117) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$432; 200 µl/$527; 500 µl/$934; 1 ml/$1,104; 2 ml/$1,479; 5 ml/$2,773

• Unconjugated
• FITC
• Cy3

• Unconjugated
• FITC
• Cy3

Select

SIGIRR Antibody LS-C676488

Antibody:

SIGIRR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

SIGIRR Antibody (C-Terminus) LS-C124546

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$748

Select

SIGIRR Antibody (HRP) LS-C549465

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$962

Select

SIGIRR Antibody (Biotin) LS-C529378

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$962

Select

SIGIRR Antibody (FITC) LS-C539299

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$962

Select

SIGIRR Antibody (PE) LS-C657445

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (PE) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

PE Conjugated

Price:

100 µl/$962

• Unconjugated
• HRP
• Biotin
• FITC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE

Select

SIGIRR Antibody LS-C779202

Antibody:

SIGIRR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$357

Select

SIGIRR Antibody (C-Terminus) LS-C187825

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse

Applications:

IHC-Fr, WB

Format:

Unconjugated

Price:

0.1 mg/$479

Select

SIGIRR Antibody (Preservative Free) LS-C815184

Antibody:

SIGIRR Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

SIGIRR Antibody LS-C489282

Antibody:

SIGIRR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Flo

Format:

Unconjugated

Price:

100 µl/$412

Select

SIGIRR Antibody LS-C489284

Antibody:

SIGIRR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

SIGIRR Antibody LS-C489285

Antibody:

SIGIRR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

SIGIRR Antibody LS-C489283

Antibody:

SIGIRR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

SIGIRR Antibody (aa334-358) LS-C816

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (aa334-358) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

0.1 mg/$386

Select

SIGIRR Antibody (aa1-118) LS-C296437

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (aa1-118) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352

Select

SIGIRR Antibody (aa1-118, Biotin) LS-C299652

Antibody:

SIGIRR Rabbit anti-Human Polyclonal (aa1-118) (Biotin) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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