SIAH1

siah E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

SIAH1 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (2)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (4)

Species

Human (7)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human SIAH1 Protein (Recombinant His) - LS-G1889

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human SIAH1 Protein (Recombinant GST) (Full Length) - LS-G30408

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

56.76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SIAH1 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60088

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SIAH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85457

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

20 µg/$150

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Human SIAH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85458

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.63 kDa

Price:

20 µg/$150

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SIAH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99946

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.63 kDa

Price:

100 µg/$494

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Human SIAH1 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145252

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

58.9 kDa

Price:

50 µg/$419

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SIAH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122184

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.4 kDa

Price:

100 µg/$494

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Human SIAH1 Protein (Recombinant GST, N-terminus) (aa1-313) - LS-G56820

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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