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SI / Sucrase Isomaltase is a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.
Gene Name: | sucrase-isomaltase (alpha-glucosidase) |
Synonyms: | SI, Alpha-glucosidase, Sucrase-isomaltase, Sucrase-isomaltase, intestinal |
Target Sequences: | NM_001041 NP_001032.2 P14410 |
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