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Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons.
Gene Name: | KIAA1598 |
Synonyms: | KIAA1598, Shootin1, Shootin-1 |
Target Sequences: | NM_018330 NP_060800.2 A0MZ66 |
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