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SHMT / SHMT1 is the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants.
Gene Name: | serine hydroxymethyltransferase 1 (soluble) |
Synonyms: | SHMT1, 14 kDa protein, CSHMT, Serine methylase, SHMT |
Target Sequences: | NM_004169 NP_004160.3 P34896 |
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