SHFM3 / FBXW4

F-box and WD repeat domain containing 4

SHFM3 / FBXW4 is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

SHFM3 / FBXW4 (4)

Publications

No (4)

Tag

6His-SUMO, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human SHFM3 / FBXW4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91564

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

20 µg/$150

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Human SHFM3 / FBXW4 Protein (Recombinant GST, N-terminus) (aa41-140) - LS-G60084

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SHFM3 / FBXW4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110506

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

100 µg/$494

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Human SHFM3 / FBXW4 Protein (Recombinant 6His-SUMO, N-terminus) (aa1-412) - LS-G56256

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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