SHANK3

SH3 and multiple ankyrin repeat domains 3

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

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Products

Antibodies (27)

Type

Primary (27)

Target

SHANK3 (27)

Reactivity

Human (26)

Mouse (25)

Rat (24)

Bovine (1)

Hamster (1)

Horse (1)

Monkey (1)

Application

IHC (22)

WB (25)

ELISA (2)

ICC (11)

IF (21)

IP (12)

Peptide-ELISA (1)

Host

rabbit (6)

mouse (21)

Isotype

IgG (5)

IgG2a (10)

IgG2b (11)

Clonality

monoclonal mc (21)

polyclonal pc (6)

Clone

S367-51 (10)

S69-46 (11)

Format

AP Conjugated (1)

APC Conjugated (2)

Atto 390 Conjugated (2)

Atto 488 Conjugated (2)

Atto 594 Conjugated (2)

Biotin Conjugated (2)

FITC Conjugated (2)

PerCP Conjugated (2)

RPE Conjugated (2)

Unconjugated (10)

Epitope

aa840-857 (11)

Internal (1)

aa1475-1525 (1)

aa1691-1741 (1)

Publications

No (26)

Yes (1)

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SHANK3 Antibody (aa1475-1525) LS-C290822

(4.0) Rating

(1) Publication(s)

Antibody:

SHANK3 Rabbit anti-Human Polyclonal (aa1475-1525) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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SHANK3 Antibody (aa840-857, clone S69-46) LS-C153129

Antibody:

SHANK3 Mouse anti-Human Monoclonal (aa840-857) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$537

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SHANK3 Antibody LS-C153697

Antibody:

SHANK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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SHANK3 Antibody (Internal) LS-C94888

Antibody:

SHANK3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

500 µg/$393

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SHANK3 Antibody (aa840-857, clone S69-46) LS-C109032

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (S69-46) Antibody

Reactivity:

Mouse, Bovine, Rat, Hamster, Horse, Human, Monkey

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$442

Select

SHANK3 Antibody (aa840-857, clone S69-46, Biotin) LS-C227765

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Biotin) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

Biotin Conjugated

Price:

100 µg/$475

Select

SHANK3 Antibody (aa840-857, clone S69-46, FITC) LS-C227766

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (FITC) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

FITC Conjugated

Price:

100 µg/$472

Select

SHANK3 Antibody (aa840-857, clone S69-46, Atto 488) LS-C229886

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Atto 488) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

Atto 488 Conjugated

Price:

100 µg/$479

Select

SHANK3 Antibody (aa840-857, clone S69-46, Atto 390) LS-C229885

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Atto 390) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

Atto 390 Conjugated

Price:

100 µg/$479

Select

SHANK3 Antibody (aa840-857, clone S69-46, Atto 594) LS-C229888

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Atto 594) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

Atto 594 Conjugated

Price:

100 µg/$479

Select

SHANK3 Antibody (aa840-857, clone S69-46, AP) LS-C227762

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (AP) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

AP Conjugated

Price:

100 µg/$474

Select

SHANK3 Antibody (aa840-857, clone S69-46, APC) LS-C227764

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (APC) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

APC Conjugated

Price:

100 µg/$478

Select

SHANK3 Antibody (aa840-857, clone S69-46, PerCP) LS-C227769

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (PerCP) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

PerCP Conjugated

Price:

100 µg/$478

Select

SHANK3 Antibody (aa840-857, clone S69-46, RPE) LS-C227770

Antibody:

SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (RPE) (S69-46) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IP, WB

Format:

RPE Conjugated

Price:

100 µg/$477

• Unconjugated
• Biotin
• FITC
• Atto 488
• Atto 390
• Atto 594
• AP
• More...
  • APC
  • PerCP
  • RPE

• Unconjugated
• Biotin
• FITC
• More...
  • Atto 488
  • Atto 390
  • Atto 594
  • AP
  • APC
  • PerCP
  • RPE

Select

SHANK3 Antibody (clone S367-51) LS-C776959

Antibody:

SHANK3 Mouse anti-Human Monoclonal (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$442

Select

SHANK3 Antibody (clone S367-51, Biotin) LS-C776956

Antibody:

SHANK3 Mouse anti-Human Monoclonal (Biotin) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Biotin Conjugated

Price:

100 µg/$475

Select

SHANK3 Antibody (clone S367-51, FITC) LS-C775910

Antibody:

SHANK3 Mouse anti-Human Monoclonal (FITC) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

FITC Conjugated

Price:

100 µg/$472

Select

SHANK3 Antibody (clone S367-51, Atto 594) LS-C773380

Antibody:

SHANK3 Mouse anti-Human Monoclonal (Atto 594) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Atto 594 Conjugated

Price:

100 µg/$479

Select

SHANK3 Antibody (clone S367-51, Atto 390) LS-C773381

Antibody:

SHANK3 Mouse anti-Human Monoclonal (Atto 390) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Atto 390 Conjugated

Price:

100 µg/$479

Select

SHANK3 Antibody (clone S367-51, Atto 488) LS-C775907

Antibody:

SHANK3 Mouse anti-Human Monoclonal (Atto 488) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Atto 488 Conjugated

Price:

100 µg/$479

Select

SHANK3 Antibody (clone S367-51, APC) LS-C776957

Antibody:

SHANK3 Mouse anti-Human Monoclonal (APC) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

APC Conjugated

Price:

100 µg/$478

Select

SHANK3 Antibody (clone S367-51, RPE) LS-C777302

Antibody:

SHANK3 Mouse anti-Human Monoclonal (RPE) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

RPE Conjugated

Price:

100 µg/$477

Select

SHANK3 Antibody (clone S367-51, PerCP) LS-C777306

Antibody:

SHANK3 Mouse anti-Human Monoclonal (PerCP) (S367-51) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

PerCP Conjugated

Price:

100 µg/$478

• Biotin
• FITC
• Atto 594
• Atto 390
• Atto 488
• APC
• RPE
• More...
  • PerCP

• Biotin
• FITC
• Atto 594
• More...
  • Atto 390
  • Atto 488
  • APC
  • RPE
  • PerCP

Select

SHANK3 Antibody LS-C779501

Antibody:

SHANK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

SHANK3 Antibody LS-C808324

Antibody:

SHANK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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