Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

SH3PXD2A / TKS5

SH3 and PX domains 2A

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.

Gene Name: SH3 and PX domains 2A
Synonyms: SH3PXD2A, Adapter protein TKS5, Adaptor protein TKS5, FISH, KIAA0418, SH3 and PX domains 2A, SH3 multiple domains protein 1, TSK5, SH3 multiple domains 1, SH3MD1, TKS5
Target Sequences: AX695698 IPI00023692.1 Q5TCZ1

Publications (2)

1
Identification of invadopodia by TKS5 staining in human cancer lines and patient tumor samples. Baik M, French B, Chen YC, Byers JT, Chen KT, French SW, Díaz B. MethodsX. 2019 March;6:718-726. [Full Text Article] [PubMed:31011543] [PMC:PMC6461573] Related Antibodies: LS-C383498.
2
TKS5-positive invadopodia-like structures in human tumor surgical specimens. Yu-Chuan Chen, Matthew Baik, Joshua T Byers, Kathryn T Chen, Samuel W French, Begoña Díaz. Experimental and molecular pathology. 2019 February;106:17-26. [Full Text Article] [PubMed:30439350] [PMC:PMC6368464] Related Antibodies: LS-C383498.

☰ Filters
Products
Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
SH3PXD2A / TKS5 (3)
No (3)
10His, N-terminus + Myc, C-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Purified (1)
SH3PXD2A / TKS5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
121.7 kDa
20 µg/$215
SH3PXD2A / TKS5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
121.7 kDa
100 µg/$710
SH3PXD2A / TKS5 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
14.0 kDa
20 µg/$364; 1 mg/$1,679; 100 µg/$500
Viewing 1-3 of 3 product results


Filtered By:
Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).