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May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Gene Name: | SH3-domain binding protein 4 |
Synonyms: | SH3BP4, BOG25, EHB10, EH-binding protein 10, SH3-domain binding protein 4, TTP, SH3 domain-binding protein 4 |
Target Sequences: | NM_014521 NP_055336.1 Q9P0V3 |
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