SH2D1A / SAP

SH2 domain containing 1A

SH2D1A / SAP is a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

SH2D1A / SAP (9)

Publications

No (9)

Tag

6His, N-terminus (2)

GST (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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Human SH2D1A / SAP Protein (Recombinant His) - LS-G1008

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human SH2D1A / SAP Protein (Recombinant 6His, N-terminus) (Met1-Pro128) - LS-G39650

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.3kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human SH2D1A / SAP Protein (Recombinant GST) (Full Length) - LS-G29231

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

39.82 kDa

Price:

10 µg/$479; 25 µg/$670

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Human SH2D1A / SAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88271

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14 kDa

Price:

20 µg/$150

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Human SH2D1A / SAP Protein (Recombinant His) (Pro2-Lys97) - LS-G97886

Source:

E. coli

Tag:

His

Molecular Weight:

15.6 kDa

Price:

100 µg/$843

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SH2D1A / SAP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99728

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14 kDa

Price:

100 µg/$494

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Human SH2D1A / SAP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70901

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14 kDa

Price:

20 µg/$1,107

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Human SH2D1A / SAP Protein (Recombinant 6His, N-terminus) (Met1-Pro128) - LS-G139202

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

16.3 kDa

Price:

10 µg/$368; 50 µg/$479

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Mouse SH2D1A / SAP Protein (Recombinant His-T7) (aa18-115) - LS-G16282

Source:

E. coli

Tag:

His-T7

Molecular Weight:

14.6 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$757; 200 µg/$945; 1 mg/$2,073; 500 µg/$1,604; 5 mg/$3,305; 2 mg/$2,262

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