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SFTPB / Surfactant Protein B

surfactant protein B

SFTPB / Surfactant Protein B is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene Name: surfactant protein B
Synonyms: SFTPB, 6 kDa protein, PSP-B, SFTP3, SP-B, SFTB3, SMDP1, Surfactant protein B
Target Sequences: NM_000542 NP_000533.3 P07988

Publications (2)

1
Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs. Kati J Dillard, Matthias Ochs, Julia E Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K Hytönen, Marjukka Anttila, Hannes Lohi. PLoS genetics. 2020 Mar;16:e1008651. [Full Text Article] [PubMed:32150563] [PMC:PMC7082050] Related Antibodies: LS-B8081.
2
Physiologically variable ventilation in a rabbit model of asthma exacerbation. André Dos Santos Rocha, Roberta Südy, Ferenc Peták, Walid Habre. British journal of anaesthesia. 2020 December;125:1107-1116. [Full Text Article] [PubMed:33070949]

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Antibodies (51)
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SFTPB / Surfactant Protein B (87)
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SFTPB / Surfactant Protein B Antibody - Anti-Surfactant Protein B / SP-B antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa194-243) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SFTPB / Surfactant Protein B Antibody - Anti-Surfactant Protein B / SP-B antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa194-243) (FITC) Antibody
Dog, Guinea pig, Rat, Pig, Gibbon, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Lung Lavage Fluid, Plasma, Serum, Tissue Homogenates
1 Plate/$798
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$929
SFTPB / Surfactant Protein B ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$913
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SFTPB / Surfactant Protein B Rabbit anti-Pig Polyclonal Antibody
Pig, Human
ELISA, WB
Unconjugated
100 µg/$589
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$715
SFTPB / Surfactant Protein B Antibody - Western blot analysis of extracts of various cell lines, using SFTPB antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 3s.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Microplate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa1-60) Antibody
Mouse, Bovine, Pig, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$862
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa1-60) Antibody
Mouse, Bovine, Pig, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$589
SFTPB / Surfactant Protein B Protein - Recombinant Surfactant Associated Protein B By SDS-PAGE
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E. coli
His
20.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
SFTPB / Surfactant Protein B Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
None
100 µg/$610; 20 µg/$447; 1 mg/$1,761
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$957
SFTPB / Surfactant Protein B Antibody - Western blot of SFTPB / Surfactant Protein B antibody.
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa201-381) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$351
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SFTPB / Surfactant Protein B Protein - Recombinant Surfactant Associated Protein B By SDS-PAGE
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E. coli
His-T7
28.3 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Lung Lavage Fluid, Tissue Homogenates
1 Plate/$750
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
25 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
SFTPB / Surfactant Protein B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SFTPB / Surfactant Protein B Protein - Recombinant  Surfactant Associated Protein B By SDS-PAGE
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E. coli
His-GST, N-terminus
51.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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SFTPB / Surfactant Protein B Rabbit anti-Human Polyclonal (aa129-158) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Viewing 1-25 of 87 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).