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Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
Gene Name: | secreted frizzled-related protein 4 |
Synonyms: | SFRP4, FRPHE, SFRP-4, FRP-4 |
Target Sequences: | NM_003014 NP_003005.2 Q6FHJ7 |
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