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SF3B130 / SF3B3
splicing factor 3b, subunit 3, 130kDa
SF3B130 / SF3B3 is subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
| Gene Name: | splicing factor 3b, subunit 3, 130kDa |
| Synonyms: | SF3B3, RSE1, Splicing factor 3B subunit 3, SAP 130, STAF130, KIAA0017, SF3b130 |
| Target Sequences: | NM_012426 NP_036558.3 Q15393 |
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