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SF3A1 / SF3A120
splicing factor 3a, subunit 1, 120kDa
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
| Gene Name: | splicing factor 3a, subunit 1, 120kDa |
| Synonyms: | SF3A1, Pre-mRNA processing 21, PRPF21, SAP 114, SAP114, SF3A120, Splicing factor 3 subunit 1, Splicing factor 3A subunit 1, PRP21 |
| Target Sequences: | NM_005877 NP_005868.1 Q15459 |
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