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SETD8 / SET8
SET domain containing (lysine methyltransferase) 8
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.
| Gene Name: | SET domain containing (lysine methyltransferase) 8 |
| Synonyms: | SETD8, KMT5A, Lysine N-methyltransferase 5A, PR/SET07, PRSET7, SET8, H4-K20-HMTase SETD8, PR-Set7, SET07 |
| Target Sequences: | NM_020382 NP_065115.3 Q9NQR1 |
Publications (1)
1
An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy. Szablewski V, Bret C, Kassambara A, Devin J, Cartron G, Costes-Martineau V, Moreaux J. Oncotarget. 2018 April;9:19079-19099. (Human)
[Full Text Article]
[PubMed:29721185]
[PMC:PMC5922379]
Related Antibodies: LS-B5237.
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SETD8 / SET8
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SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (43AT551.86) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Rat, Human
ICC, IF, WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SETD8 / SET8 Mouse anti-Human Monoclonal (7H1G10) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (43AT890) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (Biotin) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (FITC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (APC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (PE) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
SETD8 / SET8 Mouse anti-Human Monoclonal (N-Terminus) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa220-249) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SETD8 / SET8 Mouse anti-Human Monoclonal (OTI3G9) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
SETD8 / SET8 Mouse anti-Human Monoclonal (Carrier-free) (OTI3G9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SETD8 / SET8 Mouse anti-Human Monoclonal (OTI2F5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
SETD8 / SET8 Mouse anti-Human Monoclonal (Carrier-free) (OTI2F5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
SETD8 / SET8 Rabbit anti-Human Polyclonal (aa25-53) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SETD8 / SET8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
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