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Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.
Gene Name: | SET domain containing 1A |
Synonyms: | SETD1A, HSET1A, KIAA0339, Lysine N-methyltransferase 2F, KMT2F, Set1, SET domain containing 1A, Set1A |
Target Sequences: | AB002337 BAA20797.2 O15047 |
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