Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
SERPINB6 / PI-6 is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
Gene Name: | serpin peptidase inhibitor, clade B (ovalbumin), member 6 |
Synonyms: | SERPINB6, CAP, Cytoplasmic antiproteinase, DFNB91, Peptidase inhibitor 6, PI-6, PI6, PTI, Serpin B6, MSTP057, Placental thrombin inhibitor, SPI3 |
Target Sequences: | NM_004568 NP_004559.4 P35237 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.