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SERPINA1 / Alpha 1 Antitrypsin
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
| Gene Name: | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| Synonyms: | SERPINA1, A1A, A1AT, AAT, Alpha 1 Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha1AT, PRO2275, Alpha-1-antitrypsin null, PI1, Serpin A1, Alpha 1 AT |
| Target Sequences: | K02212 AAB59495.1 P01009 |
Publications (5)
1
Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation. Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ. The Journal of clinical endocrinology and metabolism. 2009 94:5053-61.
[PubMed:19837942]
2
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Molecular and cellular biology. 2011 31:1145-59. (WB, IP; Mouse)
[PubMed:21220515]
[PMC:PMC3067910]
3
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. Klemm EJ, Spooner E, Ploegh HL. The Journal of biological chemistry. 2011 286:37602-14.
[PubMed:21857022]
[PMC:PMC3199505]
☰ Filters
Products
Proteins
(49)
Type
Over-Expression Lysate
(20)
Recombinant
(28)
Target
SERPINA1 / Alpha 1 Antitrypsin
(49)
Publications
No
(49)
Tag
6His, C-terminus
(2)
6His, N-terminus
(2)
6His-SUMO, N-terminus
(1)
GST
(2)
His
(3)
His, C-Terminal
(1)
His, N-Terminal
(1)
His,C-terminus
(2)
His-T7
(1)
Myc-DDK (Flag)
(30)
Species
Human
(32)
Mouse
(3)
Rat
(4)
Source
293T Cells
(10)
E. coli
(9)
HEK 293 Cells
(22)
Human
(1)
Human Cells
(2)
Mammalian Cells
(2)
Wheat Germ Extract
(2)
Yeast
(1)
Purification
Purified
(9)
Low Endotoxin Level
Low endotoxin level
(6)
E. coli
His
45.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His, N-Terminal
46.7 kDa
50 µg/$419
E. coli
None
100 µg/$361; 500 µg/$739; 20 µg/$261
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.5 kDa
10 µg/$416; 50 µg/$910
Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
E. coli
6His, N-terminus
47 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Wheat Germ Extract
GST
71.72 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST
73.1 kDa
10 µg/$479; 25 µg/$670
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
45.35kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
44.5kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
HEK 293 Cells
Myc-DDK (Flag)
46.72 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.74 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$215
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
46.72 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
44.3 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
44.3 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
44.3 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
44.3 kDa
20 µg/$1,107
Viewing 1-25
of 49
product results
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