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SEPT4 / Septin 4
septin 4
SEPT4 / Septin 4 is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.
| Gene Name: | septin 4 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | SEPT4, Brain protein H5, ARTS, BRADEION, CE5B3, Cerebral protein 7, H5, HCDCREL-2, Peanut-like 2 (Drosophila), PNUTL2, SEP4, Septin 4, Bradeion beta, CE5B3 beta, Hucep-7, MART, Peanut-like protein 2, Septin-4, Septin-M |
| Target Sequences: | NM_004574 NP_004565.1 O43236 |
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