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Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.
Gene Name: | SUMO1/sentrin specific peptidase 1 |
Family/Subfamily: | Protease , Cysteine C48 |
Synonyms: | SENP1, Sentrin-specific protease 1, SuPr-2 |
Target Sequences: | NM_014554 NP_055369.1 Q9P0U3 |
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