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The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.
Gene Name: | Sec61 beta subunit |
Synonyms: | SEC61B, Sec61 complex, beta subunit, Sec61 beta subunit |
Target Sequences: | NM_006808 NP_006799.1 P60468 |
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