SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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Products

Antibodies (80)

Type

Primary (80)

Target

SDF1 / CXCL12 (80)

Reactivity

Human (57)

Mouse (43)

Rat (17)

Bat (3)

Chicken (3)

Chimpanzee (3)

Dog (4)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Xenopus (3)

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Application

IHC (19)

IHC-P (10)

WB (76)

ELISA (26)

ICC (1)

IP (2)

Peptide-ELISA (2)

Host

rabbit (63)

mouse (9)

goat (8)

Product Group

IHCPlus (3)

Isotype

IgG (21)

IgG2b,k (1)

Clonality

monoclonal mc (9)

polyclonal pc (71)

Clone

1E5 (1)

Format

APC (5)

APC Conjugated (6)

Azide-free (1)

Biotin Conjugated (12)

Cy3 Conjugated (5)

Cy7 Conjugated (5)

FITC Conjugated (8)

HRP Conjugated (8)

PE Conjugated (7)

Unconjugated (29)

Epitope

aa21-89 (8)

aa22-89 (8)

aa23-89 (8)

aa23-93 (8)

aa64-92 (7)

C-Terminus (5)

C-terminal (1)

Publications

No (78)

Yes (2)

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IHC-plus™ SDF1 / CXCL12 Antibody LS-B2437

(5.0) Rating

(1) Publication(s)

Antibody:

SDF1 / CXCL12 Rabbit anti-Rat Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$485

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SDF1 / CXCL12 Antibody (C-Terminus) LS-B943

(4.0) Rating

(1) Publication(s)

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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SDF1 / CXCL12 Antibody (C-Terminus, HRP) LS-C481334

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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SDF1 / CXCL12 Antibody (C-Terminus, Biotin) LS-C481332

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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SDF1 / CXCL12 Antibody (C-Terminus, FITC) LS-C481333

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

IHC-plus™ SDF1 / CXCL12 Antibody LS-B7489

(4.0) Rating

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$485

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SDF1 / CXCL12 Antibody (Biotin) LS-C104650

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

SDF1 / CXCL12 Antibody (C-terminal) LS-C386018

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SDF1 / CXCL12 Antibody (clone 1E5) LS-C198173

Antibody:

SDF1 / CXCL12 Mouse anti-Human Monoclonal (1E5) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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SDF1 / CXCL12 Antibody LS-C104385

Antibody:

SDF1 / CXCL12 Goat anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$356; 100 µg/$396

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SDF1 / CXCL12 Antibody (Biotin) LS-C104407

Antibody:

SDF1 / CXCL12 Goat anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

SDF1 / CXCL12 Antibody (aa64-92) LS-C167170

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

SDF1 / CXCL12 Antibody LS-C104733

Antibody:

SDF1 / CXCL12 Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$356; 100 µg/$396

Select

SDF1 / CXCL12 Antibody (Biotin) LS-C104644

Antibody:

SDF1 / CXCL12 Goat anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

SDF1 / CXCL12 Antibody LS-C756366

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SDF1 / CXCL12 Antibody (HRP) LS-C549659

Antibody:

SDF1 / CXCL12 Goat anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$937

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SDF1 / CXCL12 Antibody (aa22-89, Biotin) LS-C298939

Antibody:

SDF1 / CXCL12 Rabbit anti-Mouse Polyclonal (aa22-89) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248

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SDF1 / CXCL12 Antibody (aa22-89, FITC) LS-C304904

Antibody:

SDF1 / CXCL12 Rabbit anti-Mouse Polyclonal (aa22-89) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$338; 200 µl/$392; 500 µl/$573; 1 ml/$698; 2 ml/$936; 5 ml/$1,588

• Biotin
• FITC

• Biotin
• FITC

Select

SDF1 / CXCL12 Antibody (aa64-92) LS-C320697

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SDF1 / CXCL12 Antibody (aa64-92, Biotin) LS-C520210

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SDF1 / CXCL12 Antibody (aa64-92, FITC) LS-C255760

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SDF1 / CXCL12 Antibody (aa64-92, Azide-free, HRP) LS-C255761

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SDF1 / CXCL12 Antibody (aa64-92, APC) LS-C255762

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC

Select

SDF1 / CXCL12 Antibody LS-C782210

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

SDF1 / CXCL12 Antibody LS-C201162

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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