SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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Antibodies (80)

Proteins (52)

ELISA Kits (31)

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Target

SDF1 / CXCL12 (163)

Reactivity

Human (67)

Mouse (52)

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Bat (3)

Chicken (4)

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IHC-plus™ SDF1 / CXCL12 Antibody LS-B2437

(5.0) Rating

(1) Publication(s)

Antibody:

SDF1 / CXCL12 Rabbit anti-Rat Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$485

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SDF1 / CXCL12 Antibody (C-Terminus) LS-B943

(4.0) Rating

(1) Publication(s)

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ SDF1 / CXCL12 Antibody LS-B7489

(4.0) Rating

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$485

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SDF1 / CXCL12 Antibody (Biotin) LS-C104650

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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SDF1 / CXCL12 Antibody (C-terminal) LS-C386018

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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SDF1 / CXCL12 Antibody (clone 1E5) LS-C198173

Antibody:

SDF1 / CXCL12 Mouse anti-Human Monoclonal (1E5) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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SDF1 / CXCL12 Antibody LS-C104385

Antibody:

SDF1 / CXCL12 Goat anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$356; 100 µg/$396

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SDF1 / CXCL12 Antibody (Biotin) LS-C104407

Antibody:

SDF1 / CXCL12 Goat anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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SDF1 / CXCL12 Antibody (aa64-92) LS-C167170

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal (aa64-92) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F3387

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

32.77 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F5180

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$573

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Mouse SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F5181

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F5502

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$715

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Pig SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F9716

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$779

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F12575

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F21608

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G27012

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

8 kDa (SDS-PAGE)

Price:

5 µg/$304; 25 µg/$402

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SDF1 / CXCL12 Antibody LS-C104733

Antibody:

SDF1 / CXCL12 Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$356; 100 µg/$396

Select

SDF1 / CXCL12 Antibody (Biotin) LS-C104644

Antibody:

SDF1 / CXCL12 Goat anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F3386

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

93.75 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma

Price:

1 Plate/$426

Select

SDF1 / CXCL12 Antibody LS-C756366

Antibody:

SDF1 / CXCL12 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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SDF1 / CXCL12 Antibody (HRP) LS-C549659

Antibody:

SDF1 / CXCL12 Goat anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$937

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SDF1 / CXCL12 Antibody (aa22-89, Biotin) LS-C298939

Antibody:

SDF1 / CXCL12 Rabbit anti-Mouse Polyclonal (aa22-89) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248

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SDF1 / CXCL12 Antibody (aa22-89, FITC) LS-C304904

Antibody:

SDF1 / CXCL12 Rabbit anti-Mouse Polyclonal (aa22-89) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$338; 200 µl/$392; 500 µl/$573; 1 ml/$698; 2 ml/$936; 5 ml/$1,588

• Biotin
• FITC

• Biotin
• FITC

Select

Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F56575

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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