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SCNN1B / ENaC Beta
sodium channel, non-voltage-gated 1, beta subunit
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
| Gene Name: | sodium channel, non-voltage-gated 1, beta subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - amiloride-sensitive |
| Synonyms: | SCNN1B, BESC1, Beta-NaCH, Beta ENaC, Beta-ENaC, ENaC beta, ENaCb, HENaC, Liddle syndrome, RENaC, RNENACB, SCNEB, ENaCbeta |
| Target Sequences: | NM_000336 NP_000327.2 P51168 |
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