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SCNN1A / ENaC Alpha
sodium channel, non-voltage-gated 1 alpha subunit
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
| Gene Name: | sodium channel, non-voltage-gated 1 alpha subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - amiloride-sensitive |
| Synonyms: | SCNN1A, Alpha hENaC, Alpha-NaCH, Alpha-ENaC, ENaCalpha, ENaCa, ENaC alpha, HENaC alpha, Alpha ENaC-2, SCNEA, SCNN1, BESC2 |
| Target Sequences: | NM_001038 NP_001029.1 P37088 |
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