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SCN5A / Nav1.5
sodium channel, voltage-gated, type V, alpha subunit
Scn5a encodes the alpha subunit of the type V voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type V channel has been shown to be tetrodotoxin-resistant. Scn5a null mice experience intrauterine lethality. Mutations in the SCN5A gene are responsible for several heart conditions, including the chromosome 3-linked form of long LQT and Brugada syndrome.
| Gene Name: | sodium channel, voltage-gated, type V, alpha subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - voltage-gated |
| Synonyms: | SCN5A, CDCD2, CMPD2, HB1, HB2, HH1, HBBD, Nav1.5, IVF, RSKM2X, SCAL, Scn2x, LQT3, SSS1, MH1, VF1, PFHB1, RATRSKM2X, SkM2, CMD1E, ICCD, RH1, RSkM2 |
| Target Sequences: | NM_000335 NP_000326.2 Q14524 |
Publications (1)
1
Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses. Tabor KM, Bergeron SA, Horstick EJ, Jordan DC, Aho V, Porkka-Heiskanen T, Haspel G, Burgess HA. Journal of neurophysiology. 2014 112:834-44. (WB; Human)
[Full Text Article]
[PubMed:24848468]
[PMC:PMC4122749]
Related Antibodies: LS-C144743.
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SCN5A / Nav1.5
(26)
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(25)
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(4)
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(1)
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(11)
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(7)
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(4)
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SCN5A / Nav1.5 Goat anti-Human Polyclonal (aa1548-1558) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) Antibody
Human
WB
Unconjugated
400 µl/$393
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa1856-1905) Antibody
Human
WB
Unconjugated
100 µl/$424
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa1856-1905) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa1856-1905) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa1856-1905) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Pig, Horse, Mouse, Dog, Guinea pig, Bovine, Bat, Rat, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
200 µl/$468
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$357
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa42-70) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
HRP Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Monkey, Chimpanzee, Gibbon
WB
FITC Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa539-588) (HRP) Antibody
Mouse, Rat, Gibbon, Human
WB
HRP Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa539-588) (Biotin) Antibody
Mouse, Rat, Gibbon, Human
WB
Biotin Conjugated
100 µl/$469
SCN5A / Nav1.5 Rabbit anti-Human Polyclonal (aa539-588) (FITC) Antibody
Mouse, Rat, Gibbon, Human
WB
FITC Conjugated
100 µl/$469
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