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SCN10A / Nav1.8
sodium channel, voltage-gated, type X, alpha subunit
Scn10a encodes the alpha subunit of the type X voltage-gated sodium channel. These channels, composed of one alpha and one or two beta subunits, mediate changes in cell permeability to sodium ions that are essential for the generation of action potentials. The alpha subunit alone has been shown to generate a functional channel in vitro, but it's kinetic properties are modulated by beta subunits. The type X channel, which has depolarized activation potential, slow inactivation kinetics, and resistance to high concentrations of tetrodotoxin, has been implicated in nociceptive transmission. Aberrant expression of Scn10a has been demonstrated in cerebellar Purkinje cells in experimental models of multiple sclerosis (MS) and in human MS.
| Gene Name: | sodium channel, voltage-gated, type X, alpha subunit |
| Family/Subfamily: | Ion Channel , Sodium channel - voltage-gated |
| Synonyms: | SCN10A, HPN3, Nav1.8, PN3, RPN3, SNS |
| Target Sequences: | NM_006514 NP_006505.3 Q9Y5Y9 |
Publications (2)
1
The functional consequences of sodium channel NaV<sub> 1.8 in human left ventricular hypertrophy. Ahmad S, Tirilomis P, Pabel S, Dybkova N, Hartmann N, Molina CE, Tirilomis T, Kutschka I, Frey N, Maier LS, Hasenfuss G, Streckfuss-Bömeke K, Sossalla S. ESC heart failure. 2019 February;6:154-163. [Full Text Article]
[PubMed:30378291]
[PMC:PMC6352890]
Related Antibodies: LS-C109037.
2
Detrimental proarrhythmogenic interaction of Ca 2+<sup>/calmodulin-dependent protein kinase II and Na V<sub> 1.8 in heart failure. Philipp Bengel # , Nataliya Dybkova # , Petros Tirilomis # , Shakil Ahmad , Nico Hartmann , Belal A Mohamed , Miriam Celine Krekeler , Wiebke Maurer , Steffen Pabel, Maximilian Trum, Julian Mustroph, Jan Gummert, Hendrik Milting, Stefan Wagner, Senka Ljubojevic-Holzer, Karl Toischer , Lars S Maier, Gerd Hasenfuss , Katrin Streckfuss-Bömeke # , Samuel Sossalla #. Nature communications. 2021 Nov;12:6586. [Full Text Article]
[PubMed:34782600]
[PMC:PMC8593192]
Related Antibodies: LS-C109037.
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Antibodies
(23)
Type
Primary
(23)
Target
SCN10A / Nav1.8
(23)
Reactivity
Human
(22)
Mouse
(14)
Rat
(13)
Monkey
(1)
Application
IHC
(14)
IHC-P
(2)
WB
(16)
ELISA
(5)
ICC
(11)
IF
(13)
Peptide-ELISA
(2)
Host
rabbit
(11)
mouse
(11)
goat
(1)
Product Group
IHCPlus
(2)
Isotype
IgG
(8)
IgG2a
(11)
Clonality
monoclonal mc
(11)
polyclonal pc
(12)
Clone
S134-12
(10)
Format
APC Conjugated
(1)
Atto 390 Conjugated
(1)
Atto 488 Conjugated
(1)
Atto 594 Conjugated
(1)
Biotin Conjugated
(2)
FITC Conjugated
(2)
HRP Conjugated
(1)
PerCP Conjugated
(1)
RPE Conjugated
(1)
Unconjugated
(12)
Epitope
aa1724-1956
(9)
C-Terminus
(2)
aa31-45
(2)
aa471-484
(1)
Publications
No
(22)
Yes
(1)
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (S134-12) Antibody
Mouse, Rat, Human
ICC, IHC, WB
Unconjugated
100 µg/$442
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (Biotin) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Biotin Conjugated
100 µg/$475
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (FITC) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
FITC Conjugated
100 µg/$472
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (APC) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
APC Conjugated
100 µg/$478
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (Atto 390) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Atto 390 Conjugated
100 µg/$479
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (Atto 594) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Atto 594 Conjugated
100 µg/$479
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (Atto 488) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Atto 488 Conjugated
100 µg/$479
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (PerCP) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
PerCP Conjugated
100 µg/$478
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (aa1724-1956) (RPE) (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
RPE Conjugated
100 µg/$477
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal (aa31-45) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
60 µl/$460
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$440; 100 µg/$480
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, WB
Unconjugated
200 µl/$468
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$485
SCN10A / Nav1.8 Goat anti-Mouse Polyclonal (aa471-484) Antibody
Mouse
Peptide-ELISA
Unconjugated
100 µg/$401
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$351
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal (aa31-45) Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$248
SCN10A / Nav1.8 Mouse anti-Rat Monoclonal (S134-12) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µg/$537
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
SCN10A / Nav1.8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$357
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of 23
product results
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