SCARB1 / SR-BI

4

Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1. Wang N, Silver DL, Costet P, Tall AR. The Journal of biological chemistry. 2000 275:33053-8. [PubMed:10918065]

5

Sterol carrier protein-2 alters high density lipoprotein-mediated cholesterol efflux. Atshaves BP, Starodub O, McIntosh A, Petrescu A, Roths JB, Kier AB, Schroeder F. The Journal of biological chemistry. 2000 275:36852-61. [PubMed:10954705]

6

Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells. Witt W, Kolleck I, Fechner H, Sinha P, Rstow B. Journal of lipid research. 2000 41:2009-16. [PubMed:11108734]

7

Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid. Husemann J, Loike JD, Kodama T, Silverstein SC. Journal of neuroimmunology. 2001 114:142-50. [PubMed:11240025]

8

Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. Han J, Nicholson AC, Zhou X, Feng J, Gotto AM, Hajjar DP. The Journal of biological chemistry. 2001 276:16567-72. [PubMed:11278882]

9

Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. Ohgami N, Nagai R, Miyazaki A, Ikemoto M, Arai H, Horiuchi S, Nakayama H. The Journal of biological chemistry. 2001 276:13348-55. [PubMed:11278947]

10

High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion. Silver DL, Wang N, Xiao X, Tall AR. The Journal of biological chemistry. 2001 276:25287-93. [PubMed:11301333]

11

Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine. Cai SF, Kirby RJ, Howles PN, Hui DY. Journal of lipid research. 2001 42:902-9. [PubMed:11369797]

12

p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. Hullinger TG, Panek RL, Xu X, Karathanasis SK. The Journal of biological chemistry. 2001 276:46807-14. [PubMed:11585816]

13

Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements. Tsuruoka H, Khovidhunkit W, Brown BE, Fluhr JW, Elias PM, Feingold KR. The Journal of biological chemistry. 2002 277:2916-22. [PubMed:11707442]

14

ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression. Huang ZH, Mazzone T. Journal of lipid research. 2002 43:375-82. [PubMed:11893773]

15

Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model. Goti D, Balazs Z, Panzenboeck U, Hrzenjak A, Reicher H, Wagner E, Zechner R, Malle E, Sattler W. The Journal of biological chemistry. 2002 277:28537-44. [PubMed:12032155]

16

A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver. Silver DL. The Journal of biological chemistry. 2002 277:34042-7. [PubMed:12119305]

17

ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. Panzenboeck U, Balazs Z, Sovic A, Hrzenjak A, Levak-Frank S, Wintersperger A, Malle E, Sattler W. The Journal of biological chemistry. 2002 277:42781-9. [PubMed:12202492]

18

Evidence for a Trypanosoma brucei lipoprotein scavenger receptor. Green HP, Del Pilar Molina Portela M, St Jean EN, Lugli EB, Raper J. The Journal of biological chemistry. 2003 278:422-7. [PubMed:12401813]

19

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis. Lambert G, Amar MJ, Guo G, Brewer HB, Gonzalez FJ, Sinal CJ. The Journal of biological chemistry. 2003 278:2563-70. [PubMed:12421815]

20

Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Willner EL, Tow B, Buhman KK, Wilson M, Sanan DA, Rudel LL, Farese RV. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:1262-7. [PubMed:12538880] [PMC:PMC298761]

21

Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations. Basso F, Freeman L, Knapper CL, Remaley A, Stonik J, Neufeld EB, Tansey T, Amar MJ, Fruchart-Najib J, Duverger N, Santamarina-Fojo S, Brewer HB. Journal of lipid research. 2003 44:296-302. (WB; Mouse) [PubMed:12576511]

22

Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. Vishnyakova TG, Bocharov AV, Baranova IN, Chen Z, Remaley AT, Csako G, Eggerman TL, Patterson AP. The Journal of biological chemistry. 2003 278:22771-80. [PubMed:12651854]

23

Phosphatidylinositol promotes cholesterol transport and excretion. Burgess JW, Boucher J, Neville TA, Rouillard P, Stamler C, Zachariah S, Sparks DL. Journal of lipid research. 2003 44:1355-63. [PubMed:12700341]

24

Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. Silver DL, Wang N, Vogel S. The Journal of biological chemistry. 2003 278:28528-32. [PubMed:12754212]

25

Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Hsu M, Zhang J, Flint M, Logvinoff C, Cheng-Mayer C, Rice CM, McKeating JA. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:7271-6. (Flo; Human) [PubMed:12761383] [PMC:PMC165865]

26

Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol. Sehayek E, Wang R, Ono JG, Zinchuk VS, Duncan EM, Shefer S, Vance DE, Ananthanarayanan M, Chait BT, Breslow JL. Journal of lipid research. 2003 44:1605-13. [PubMed:12810817]

27

Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice. Lundsen T, Liao W, Angelin B, Rudling M. The Journal of biological chemistry. 2003 278:43224-8. [PubMed:12917427]

28

Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells and high-density lipoprotein. Peng Y, Akmentin W, Connelly MA, Lund-Katz S, Phillips MC, Williams DL. Molecular biology of the cell. 2004 15:384-96. [PubMed:14528013] [PMC:PMC307555]

29

Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M. The Journal of biological chemistry. 2003 278:52820-5. [PubMed:14551195]

30

Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice. Fu T, Kozarsky KF, Borensztajn J. The Journal of biological chemistry. 2003 278:52559-63. [PubMed:14570884]

31

Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism. Thompson CJ, Ross SM, Gaido KW. Endocrinology. 2004 145:1227-37. [PubMed:14617579]

32

Ontogeny, immunolocalisation, distribution and function of SR-BI in the human intestine. Levy E, Mnard D, Suc I, Delvin E, Marcil V, Brissette L, Thibault L, Bendayan M. Journal of cell science. 2004 117:327-37. [PubMed:14676281]

33

Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Bland ML, Fowkes RC, Ingraham HA. Molecular endocrinology (Baltimore, Md.). 2004 18:941-52. [PubMed:14726490]

34

Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, Jessup W. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 18:574-6. [PubMed:14734645]

35

Aberrant cholesterol transport and impaired steroidogenesis in Leydig cells lacking estrogen sulfotransferase. Tong MH, Christenson LK, Song WC. Endocrinology. 2004 145:2487-97. [PubMed:14749355]

36

ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes. Sahoo D, Trischuk TC, Chan T, Drover VA, Ho S, Chimini G, Agellon LB, Agnihotri R, Francis GA, Lehner R. Journal of lipid research. 2004 45:1122-31. (WB; Rat) [PubMed:14993246]

37

Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet. Akiyama TE, Lambert G, Nicol CJ, Matsusue K, Peters JM, Brewer HB, Gonzalez FJ. The Journal of biological chemistry. 2004 279:20874-81. [PubMed:15001574]

38

Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. Wu JE, Basso F, Shamburek RD, Amar MJ, Vaisman B, Szakacs G, Joyce C, Tansey T, Freeman L, Paigen BJ, Thomas F, Brewer HB, Santamarina-Fojo S. The Journal of biological chemistry. 2004 279:22913-25. [PubMed:15044450]

39

Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester. Parathath S, Sahoo D, Darlington YF, Peng Y, Collins HL, Rothblat GH, Williams DL, Connelly MA. The Journal of biological chemistry. 2004 279:24976-85. [PubMed:15060063]

40

Targeting of scavenger receptor class B type I by synthetic amphipathic alpha-helical-containing peptides blocks lipopolysaccharide (LPS) uptake and LPS-induced pro-inflammatory cytokine responses in THP-1 monocyte cells. Bocharov AV, Baranova IN, Vishnyakova TG, Remaley AT, Csako G, Thomas F, Patterson AP, Eggerman TL. The Journal of biological chemistry. 2004 279:36072-82. (Human) [PubMed:15199068]

41

Localization and regulation of SR-BI in membrane rafts of HepG2 cells. Rhainds D, Bourgeois P, Bourret G, Huard K, Falstrault L, Brissette L. Journal of cell science. 2004 117:3095-105. [PubMed:15226391]

42

Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome. Vaziri ND, Liang KH. Circulation. 2004 110:419-25. [PubMed:15262831]

43

HMG-CoA reductase inhibition reverses LCAT and LDL receptor deficiencies and improves HDL in rats with chronic renal failure. Liang K, Kim CH, Vaziri ND. American journal of physiology. Renal physiology. 2005 288:F539-44. [PubMed:15507547]

44

Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell. Kashiwakura Y, Watanabe M, Kusumi N, Sumiyoshi K, Nasu Y, Yamada H, Sawamura T, Kumon H, Takei K, Daida H. Circulation. 2004 110:3329-34. [PubMed:15545517]

45

Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis. Merched AJ, Chan L. Circulation. 2004 110:3830-41. [PubMed:15596565]

46

Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. Brodeur MR, Luangrath V, Bourret G, Falstrault L, Brissette L. Journal of lipid research. 2005 46:687-96. [PubMed:15654132]

47

Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors. Lemieux C, Glinas Y, Lalonde J, Labrie F, Cianflone K, Deshaies Y. Journal of lipid research. 2005 46:1285-94. (WB; Rat) [PubMed:15741653]

48

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. Lalanne F, Lambert G, Amar MJ, Chtiveaux M, Zar Y, Jarnoux AL, Ouguerram K, Friburg J, Seidah NG, Brewer HB, Krempf M, Costet P. Journal of lipid research. 2005 46:1312-9. [PubMed:15741654]

49

Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes. Barth H, Cerino R, Arcuri M, Hoffmann M, Schrmann P, Adah MI, Gissler B, Zhao X, Ghisetti V, Lavezzo B, Blum HE, von Weizscker F, Vitelli A, Scarselli E, Baumert TF. Journal of virology. 2005 79:5774-85. [PubMed:15827192] [PMC:PMC1082724]

50

Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages. Francone OL, Royer L, Boucher G, Haghpassand M, Freeman A, Brees D, Aiello RJ. Arteriosclerosis, thrombosis, and vascular biology. 2005 25:1198-205. [PubMed:15831807]

51

Domain-specific lipid distribution in macrophage plasma membranes. Gaus K, Rodriguez M, Ruberu KR, Gelissen I, Sloane TM, Kritharides L, Jessup W. Journal of lipid research. 2005 46:1526-38. [PubMed:15863834]

52

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Johansson L, Rudling M, Scanlan TS, Lundsen T, Webb P, Baxter J, Angelin B, Parini P. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:10297-302. (WB; Mouse) [PubMed:16006512] [PMC:PMC1177400]

53

Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1. Nakamura T, Shibata N, Nishimoto-Shibata T, Feng D, Ikemoto M, Motojima K, Iso-O N, Tsukamoto K, Tsujimoto M, Arai H. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:13404-9. [PubMed:16174736] [PMC:PMC1224665]

54

Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy. Harder CJ, Vassiliou G, McBride HM, McPherson R. Journal of lipid research. 2006 47:492-503. [PubMed:16339112]

55

Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility. Yesilaltay A, Morales MG, Amigo L, Zanlungo S, Rigotti A, Karackattu SL, Donahee MH, Kozarsky KF, Krieger M. Endocrinology. 2006 147:1577-88. [PubMed:16410302]

56

NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. Zhang C, Yin W, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y, Li Q, Hou H, Cai M, Xiao J. Journal of lipid research. 2006 47:2055-63. (WB; Pig) [PubMed:16807312]

57

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats. Thoms-Moy E, Gianotti M, Proenza AM, Llad I. Journal of lipid research. 2006 47:2042-8. [PubMed:16816326]

58

Localization and role of NPC1L1 in cholesterol absorption in human intestine. San AT, Sinnett D, Delvin E, Bendayan M, Marcil V, Mnard D, Beaulieu JF, Levy E. Journal of lipid research. 2006 47:2112-20. [PubMed:16829661]

59

The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis. Akpovi CD, Yoon SR, Vitale ML, Pelletier RM. Journal of lipid research. 2006 47:2233-47. [PubMed:16861621]

60

LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. Azhar S, Medicherla S, Shen WJ, Fujioka Y, Fong LG, Reaven E, Cooper AD. Journal of lipid research. 2006 47:2538-50. [PubMed:16929031] [PMC:PMC1855269]

61

Persistent hepatitis C virus infection in vitro: coevolution of virus and host. Zhong J, Gastaminza P, Chung J, Stamataki Z, Isogawa M, Cheng G, McKeating JA, Chisari FV. Journal of virology. 2006 80:11082-93. [PubMed:16956932] [PMC:PMC1642175]

62

Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition. Wadsack C, Tabano S, Maier A, Hiden U, Alvino G, Cozzi V, Httinger M, Schneider WJ, Lang U, Cetin I, Desoye G. American journal of physiology. Endocrinology and metabolism. 2007 292:E476-84. [PubMed:17003234]

63

Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways. Zhang Y, Ahmed AM, McFarlane N, Capone C, Boreham DR, Truant R, Igdoura SA, Trigatti BL. Journal of lipid research. 2007 48:405-16. [PubMed:17079793]

64

E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, Orringer D, Trikha P, Saavedra HI, Leone G. Molecular and cellular biology. 2007 27:65-78. [PubMed:17167174] [PMC:PMC1800646]

65

Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice. Qu S, Perdomo G, Su D, D'Souza FM, Shachter NS, Dong HH. Journal of lipid research. 2007 48:1476-87. [PubMed:17438339] [PMC:PMC2665252]

66

SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes. Atshaves BP, McIntosh AL, Payne HR, Gallegos AM, Landrock K, Maeda N, Kier AB, Schroeder F. Journal of lipid research. 2007 48:2193-211. [PubMed:17609524]

67

Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. During A, Harrison EH. Journal of lipid research. 2007 48:2283-94. [PubMed:17644776]

68

Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo. Van Eck M, Hoekstra M, Out R, Bos IS, Kruijt JK, Hildebrand RB, Van Berkel TJ. Journal of lipid research. 2008 49:136-46. [PubMed:17954936]

69

SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL. Yvan-Charvet L, Pagler TA, Wang N, Senokuchi T, Brundert M, Li H, Rinninger F, Tall AR. Journal of lipid research. 2008 49:107-14. [PubMed:17960026]

70

Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI. Valiyaveettil M, Kar N, Ashraf MZ, Byzova TV, Febbraio M, Podrez EA. Blood. 2008 111:1962-71. [PubMed:17993610] [PMC:PMC2234045]

71

Hormonal regulation of testicular steroid and cholesterol homeostasis. Eacker SM, Agrawal N, Qian K, Dichek HL, Gong EY, Lee K, Braun RE. Molecular endocrinology (Baltimore, Md.). 2008 22:623-35. [PubMed:18032697] [PMC:PMC2262169]

72

Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion. Tietge UJ, Nijstad N, Havinga R, Baller JF, van der Sluijs FH, Bloks VW, Gautier T, Kuipers F. Journal of lipid research. 2008 49:563-71. [PubMed:18037706]

73

Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells. Barth H, Schnober EK, Neumann-Haefelin C, Thumann C, Zeisel MB, Diepolder HM, Hu Z, Liang TJ, Blum HE, Thimme R, Lambotin M, Baumert TF. Journal of virology. 2008 82:3466-79. [PubMed:18216094] [PMC:PMC2268490]

74

Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake. Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E. Journal of lipid research. 2008 49:961-72. (WB; Human) [PubMed:18235139]

75

Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters. Ashraf MZ, Kar NS, Chen X, Choi J, Salomon RG, Febbraio M, Podrez EA. The Journal of biological chemistry. 2008 283:10408-14. [PubMed:18285332] [PMC:PMC2447666]

76

CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. Drover VA, Nguyen DV, Bastie CC, Darlington YF, Abumrad NA, Pessin JE, London E, Sahoo D, Phillips MC. The Journal of biological chemistry. 2008 283:13108-15. [PubMed:18332148] [PMC:PMC2442355]

77

Scavenger receptor class B type I localizes to a late endosomal compartment. Ahras M, Naing T, McPherson R. Journal of lipid research. 2008 49:1569-76. [PubMed:18375996]

78

Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression. Tancevski I, Wehinger A, Demetz E, Eller P, Duwensee K, Huber J, Hochegger K, Schgoer W, Fievet C, Stellaard F, Rudling M, Patsch JR, Ritsch A. Endocrinology. 2008 149:3708-12. [PubMed:18388200] [PMC:PMC2993050]

79

Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. During A, Doraiswamy S, Harrison EH. Journal of lipid research. 2008 49:1715-24. [PubMed:18424859] [PMC:PMC2444002]

80

Infection induces a positive acute phase apolipoprotein E response from a negative acute phase gene: role of hepatic LDL receptors. Li L, Thompson PA, Kitchens RL. Journal of lipid research. 2008 49:1782-93. [PubMed:18497424] [PMC:PMC2444006]

81

Role of caveolin-1 in the regulation of lipoprotein metabolism. Frank PG, Pavlides S, Cheung MW, Daumer K, Lisanti MP. American journal of physiology. Cell physiology. 2008 295:C242-8. [PubMed:18508910] [PMC:PMC2493562]

82

Regulation of direct transintestinal cholesterol excretion in mice. van der Velde AE, Vrins CL, van den Oever K, Seemann I, Oude Elferink RP, van Eck M, Kuipers F, Groen AK. American journal of physiology. Gastrointestinal and liver physiology. 2008 295:G203-G208. [PubMed:18511744]

83

Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. Karpac J, Czyzewska K, Kern A, Brush RS, Anderson RE, Hochgeschwender U. American journal of physiology. Endocrinology and metabolism. 2008 295:E446-55. [PubMed:18559987]

84

LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase. Bulat N, Waeber G, Widmann C. Journal of lipid research. 2009 50:81-9. [PubMed:18757346]

85

Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. Martin GG, Atshaves BP, McIntosh AL, Mackie JT, Kier AB, Schroeder F. The Journal of nutrition. 2008 138:1859-65. [PubMed:18806093] [PMC:PMC2835297]

86

Expression of scavenger receptor-BI and low-density lipoprotein receptor and differential use of lipoproteins to support early steroidogenesis in luteinizing macaque granulosa cells. Cherian-Shaw M, Puttabyatappa M, Greason E, Rodriguez A, VandeVoort CA, Chaffin CL. Endocrinology. 2009 150:957-65. [PubMed:18832102] [PMC:PMC2646541]

87

A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase. Robichaud JC, Francis GA, Vance DE. The Journal of biological chemistry. 2008 283:35496-506. [PubMed:18842588]

88

IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Shimizu E, Kawahara K, Kajizono M, Sawada M, Nakayama H. Journal of immunology (Baltimore, Md. : 1950). 2008 181:6503-13. [PubMed:18941241]

89

CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products. Iwao Y, Nakajou K, Nagai R, Kitamura K, Anraku M, Maruyama T, Otagiri M. American journal of physiology. Renal physiology. 2008 295:F1871-80. [PubMed:18971214]

90

Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. Burke KT, Colvin PL, Myatt L, Graf GA, Schroeder F, Woollett LA. Journal of lipid research. 2009 50:1146-55. [PubMed:19122238] [PMC:PMC2681396]

91

Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice. Atshaves BP, McIntosh AL, Martin GG, Landrock D, Payne HR, Bhuvanendran S, Landrock KK, Lyuksyutova OI, Johnson JD, Macfarlane RD, Kier AB, Schroeder F. Journal of lipid research. 2009 50:1429-47. [PubMed:19289417] [PMC:PMC2694341]

92

Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. Karasinska JM, Rinninger F, Ltjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:3579-89. [PubMed:19295162] [PMC:PMC2678874]

93

Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells. Liang H, Russell RS, Yonkers NL, McDonald D, Rodriguez B, Harding CV, Anthony DD. Journal of virology. 2009 83:5693-707. [PubMed:19297478] [PMC:PMC2681964]

94

Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney. Kim HJ, Moradi H, Yuan J, Norris K, Vaziri ND. American journal of physiology. Renal physiology. 2009 296:F1297-306. [PubMed:19357177] [PMC:PMC2692452]

95

CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. Bujold K, Rhainds D, Jossart C, Febbraio M, Marleau S, Ong H. Cardiovascular research. 2009 83:457-64. [PubMed:19377069]

96

Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis. Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S. Journal of lipid research. 2009 50:2299-305. [PubMed:19458386] [PMC:PMC2759836]

97

The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. Benedicto I, Molina-Jimnez F, Bartosch B, Cosset FL, Lavillette D, Prieto J, Moreno-Otero R, Valenzuela-Fernndez A, Aldabe R, Lpez-Cabrera M, Majano PL. Journal of virology. 2009 83:8012-20. [PubMed:19515778] [PMC:PMC2715771]

98

Mechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells. Zhu P, Liu X, Treml LS, Cancro MP, Freedman BD. The Journal of biological chemistry. 2009 284:22878-87. [PubMed:19542230] [PMC:PMC2755695]

99

Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo MS, Cao G, Jiang XC. Circulation research. 2009 105:295-303. [PubMed:19590047] [PMC:PMC2746935]

100

Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages. Hongo S, Watanabe T, Arita S, Kanome T, Kageyama H, Shioda S, Miyazaki A. American journal of physiology. Endocrinology and metabolism. 2009 297:E474-82. [PubMed:19625677]

101

Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T. Circulation research. 2009 105:500-10. [PubMed:19644050]

102

CFTR knockdown stimulates lipid synthesis and transport in intestinal Caco-2/15 cells. Mailhot G, Ravid Z, Barchi S, Moreau A, Rabasa-Lhoret R, Levy E. American journal of physiology. Gastrointestinal and liver physiology. 2009 297:G1239-49. [PubMed:19808659]

103

An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI. Song X, Fischer P, Chen X, Burton C, Wang J. International journal of biological sciences. 2009 5:637-46. [PubMed:19847320] [PMC:PMC2764346]

104

Mouse-specific residues of claudin-1 limit hepatitis C virus genotype 2a infection in a human hepatocyte cell line. Haid S, Windisch MP, Bartenschlager R, Pietschmann T. Journal of virology. 2010 84:964-75. [PubMed:19889758] [PMC:PMC2798385]

105

High glucose stimulates macrophage SR-BI expression and induces a switch in its activity from cholesterol efflux to cholesterol influx. Gantman A, Fuhrman B, Aviram M, Hayek T. Biochemical and biophysical research communications. 2010 391:523-8. [PubMed:19941833]

106

The role of scavenger receptor B1 in infection with Mycobacterium tuberculosis in a murine model. Schfer G, Guler R, Murray G, Brombacher F, Brown GD. PloS one. 2009 4:e8448. [PubMed:20041149] [PMC:PMC2794535]

107

Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels. Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD. The Journal of nutrition. 2010 140:723-30. (WB; Mouse, Rat) [PubMed:20164366] [PMC:PMC2838621]

108

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes. Koller E, Vincent TM, Chappell A, De S, Manoharan M, Bennett CF. Nucleic acids research. 2011 39:4795-807. [PubMed:21345934] [PMC:PMC3113586]

109

Differential stimulation pathways of progesterone secretion from newly formed corpora lutea in rats treated with ethylene glycol monomethyl ether, sulpiride, or atrazine. Taketa Y, Yoshida M, Inoue K, Takahashi M, Sakamoto Y, Watanabe G, Taya K, Yamate J, Nishikawa A. Toxicological sciences : an official journal of the Society of Toxicology. 2011 121:267-78. (IHC; Rat) [PubMed:21427058]

110

Nephrotic syndrome causes upregulation of HDL endocytic receptor and PDZK-1-dependent downregulation of HDL docking receptor. Vaziri ND, Gollapudi P, Han S, Farahmand G, Yuan J, Rahimi A, Moradi H. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2011 26:3118-23. (IHC, WB; Rat) [PubMed:21459782]

111

Scavenger receptor SR-BI in macrophage lipid metabolism. Ji A, Meyer JM, Cai L, Akinmusire A, de Beer MC, Webb NR, van der Westhuyzen DR. Atherosclerosis. 2011 217:106-12. [PubMed:21481393] [PMC:PMC3139003]

112

Extracellular disulfide bonds support scavenger receptor class B type I-mediated cholesterol transport. Papale GA, Hanson PJ, Sahoo D. Biochemistry. 2011 50:6245-54. [PubMed:21675794]

113

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, Suen DF, Youle RJ, Amar M, Remaley AT, Sack MN. The Journal of clinical investigation. 2011 121:3701-12. [PubMed:21865652] [PMC:PMC3171101]

114

Identification of dehydroxytrichostatin A as a novel up-regulator of the ATP-binding cassette transporter A1 (ABCA1). Xu Y, Xu Y, Bao Y, Hong B, Si S. Molecules (Basel, Switzerland). 2011 16:7183-98. [PubMed:21869747]

115

Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T. Arteriosclerosis, thrombosis, and vascular biology. 2012 32:291-8. [PubMed:22095983]

116

13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. Kmmerer I, Ringseis R, Biemann R, Wen G, Eder K. Lipids in health and disease. 2011 10:222. [PubMed:22129452] [PMC:PMC3248880]

117

Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice. de Boer JF, Annema W, Schreurs M, van der Veen JN, van der Giet M, Nijstad N, Kuipers F, Tietge UJ. Journal of lipid research. 2012 53:348-57. [PubMed:22180634] [PMC:PMC3276458]

118

Nascent HDL formation in hepatocytes and role of ABCA1, ABCG1, and SR-BI. Ji A, Wroblewski JM, Cai L, de Beer MC, Webb NR, van der Westhuyzen DR. Journal of lipid research. 2012 53:446-55. [PubMed:22190590] [PMC:PMC3276468]

119

Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. Kuang YL, Paulson KE, Lichtenstein AH, Lamon-Fava S. The British journal of nutrition. 2012 108:1351-9. [PubMed:22221450]

120

Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes. Storey SM, McIntosh AL, Huang H, Landrock KK, Martin GG, Landrock D, Payne HR, Atshaves BP, Kier AB, Schroeder F. American journal of physiology. Gastrointestinal and liver physiology. 2012 302:G824-39. (ICC, WB; Mouse) [PubMed:22241858] [PMC:PMC3355564]

121

Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle. Molina-Jimenez F, Benedicto I, Dao Thi VL, Gondar V, Lavillette D, Marin JJ, Briz O, Moreno-Otero R, Aldabe R, Baumert TF, Cosset FL, Lopez-Cabrera M, Majano PL. Virology. 2012 425:31-9. [PubMed:22280897]

122

Modified high-density lipoprotein modulates aldosterone release through scavenger receptors via extra cellular signal-regulated kinase and Janus kinase-dependent pathways. Saha S, Graessler J, Schwarz PE, Goettsch C, Bornstein SR, Kopprasch S. Molecular and cellular biochemistry. 2012 366:10-Jan. (WB; Human) [PubMed:22382638]

123

Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. Sticozzi C, Belmonte G, Pecorelli A, Arezzini B, Gardi C, Maioli E, Miracco C, Toscano M, Forman HJ, Valacchi G. PloS one. 2012 7:e33592. [PubMed:22442701] [PMC:PMC3307738]

124

Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams. Broderius M, Mostad E, Prohaska JR. Genes & nutrition. 2012 7:405-14. (WB; Rat) [PubMed:22457245] [PMC:PMC3380187]

125

Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol. Grefhorst A, Oosterveer MH, Brufau G, Boesjes M, Kuipers F, Groen AK. Atherosclerosis. 2012 222:382-9. (WB; Mouse) [PubMed:22481067]

126

Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model. Estronca LM, Silva JC, Sampaio JL, Shevchenko A, Verkade P, Vaz AD, Vaz WL, Vieira OV. PloS one. 2012 7:e34822. (Mouse) [PubMed:22514671] [PMC:PMC3325953]

127

The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis. Zhou LL, Cao W, Xie C, Tian J, Zhou Z, Zhou Q, Zhu P, Li A, Liu Y, Miyata T, Hou FF, Nie J. Kidney international. 2012 82:759-70. (Flo; Mouse) [PubMed:22622498]

128

Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. Lundsen T, Andersson EM, Snaith M, Lindmark H, Lundberg J, stlund-Lindqvist AM, Angelin B, Rudling M. PloS one. 2012 7:e37787. (WB; Mouse) [PubMed:22662222] [PMC:PMC3360597]

129

Host HDL biogenesis machinery is recruited to the inclusion of Chlamydia trachomatis-infected cells and regulates chlamydial growth. Cox JV, Naher N, Abdelrahman YM, Belland RJ. Cellular microbiology. 2012 14:1497-512. (ICC; Human) [PubMed:22672264] [PMC:PMC3443303]

130

Effects of mixed micellar lipids on carotenoid uptake by human intestinal Caco-2 cells. Kotake-Nara E, Nagao A. Bioscience, biotechnology, and biochemistry. 2012 76:875-82. (WB; Human) [PubMed:22738952]

131

Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. Dao Thi VL, Granier C, Zeisel MB, Gurin M, Mancip J, Granio O, Penin F, Lavillette D, Bartenschlager R, Baumert TF, Cosset FL, Dreux M. The Journal of biological chemistry. 2012 287:31242-57. (WB; Human) [PubMed:22767607] [PMC:PMC3438956]

132

Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells. Grenier E, Garofalo C, Delvin E, Levy E. PloS one. 2012 7:e40992. (WB; Human) [PubMed:22844422] [PMC:PMC3402548]

133

ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. Wang CY, Jenkitkasemwong S, Duarte S, Sparkman BK, Shawki A, Mackenzie B, Knutson MD. The Journal of biological chemistry. 2012 287:34032-43. (WB; Rat) [PubMed:22898811] [PMC:PMC3464513]

134

Functional characterization of newly-discovered mutations in human SR-BI. Chadwick AC, Sahoo D. PloS one. 2012 7:e45660. (WB, Flo; Primate) [PubMed:23029167] [PMC:PMC3448639]

135

Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Maitra U, Li L. Arteriosclerosis, thrombosis, and vascular biology. 2013 33:24-33. (WB; Mouse) [PubMed:23117655] [PMC:PMC3545450]

136

Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport invivo. Escol-Gil JC, Julve J, Llaverias G, Urpi-Sarda M, Silvennoinen R, Lee-Rueckert M, Andres-Lacueva C, Blanco-Vaca F. Translational research : the journal of laboratory and clinical medicine. 2013 161:110-7. (WB; Mouse) [PubMed:23146569]

137

CD36-related protein in Schistosoma japonicum: candidate mediator of selective cholesteryl ester uptake from high-density lipoprotein for egg maturation. Okumura-Noji K, Miura Y, Lu R, Asai K, Ohta N, Brindley PJ, Yokoyama S. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 27:1236-44. (WB; Mouse) [PubMed:23195036]

138

Knock-down of the oxysterol receptor LXR impairs cholesterol efflux in human primary macrophages: Lack of compensation by LXR activation. Ma S, Yu H, Zhao Z, Luo Z, Chen J, Ni Y, Jin R, Ma L, Wang P, Zhu Z, Li L, Zhong J, Liu D, Nilius B, Zhu Z. Biochemical pharmacology. 2013 (WB; Human) [PubMed:23313547]

139

Mechanism for the selective uptake of macular carotenoids mediated by the HDL cholesterol receptor SR-BI. Binxing Li, Evan W George, Preejith Vachali, Fu-Yen Chang, Aruna Gorusupudi, Ranganathan Arunkumar, Nathan A Giauque, Zihe Wan, Jeanne M Frederick, Paul S Bernstein. Experimental eye research. 2023 April;229:109429. [Full Text Article] [PubMed:36863431] [PMC:PMC10121939] Related Antibodies: LS-C2880.

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Gene Name:	scavenger receptor class B, member 1
Synonyms:	SCARB1, CLA-1, CLA1, CD36 and LIMPII analogous 1, CD36 antigen-like 1, CD36L1, HDLQTL6, SR-BI, SRB1, CD36 antigen
Target Sequences:	NM_005505 NP_005496.4 Q8WTV0

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SCARB1 / SR-BI

scavenger receptor class B, member 1

Publications (139)

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