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Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Gene Name: | SAM domain, SH3 domain and nuclear localization signals 1 |
Synonyms: | SAMSN1, SH3-SAM adaptor protein, NASH1, SASH2, SLy2, HACS1, SH3D6B |
Target Sequences: | NM_022136 NP_071419.3 Q9NSI8 |
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