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The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Gene Name: | SUMO1 activating enzyme subunit 1 |
Synonyms: | SAE1, Activator of SUMO1, AOS1, UBLE1A, HSPC140, SUA1 |
Target Sequences: | NM_005500 NP_005491.1 Q9UBE0 |
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