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SAA1 / SAA / Serum Amyloid A

serum amyloid A1

SAA1 / SAA / Serum Amyloid A is a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.

Gene Name:	serum amyloid A1
Synonyms:	SAA1, Serum amyloid A protein, Serum Amyloid A, Serum amyloid A-1 protein, TP53I4, SAA, Serum amyloid A1, PIG4
Target Sequences:	NM_000331 NP_000322.2 P02735

Publications (9)

The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer. Zhang XY, Zhang G, Jiang Y, Liu D, Li MZ, Zhong Q, Zeng SQ, Liu WL, Zeng MS. Chinese journal of cancer. 2015 34:335-49. (ELISA; Human) [Full Text Article] [PubMed:26264146] [PMC:PMC4593389] Related Antibodies: LS-C20534.

Serum amyloid A, an acute phase protein, stimulates proliferative and proinflammatory responses of keratinocytes. Yu N, Zhang S, Lu J, Li Y, Yi X, Tang L, Su L, Ding Y. Cell proliferation. 2017 June;50: [Full Text Article] [PubMed:27910163]

Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function. Xiliang Du, Guowen Liu, Juan J Loor, Zhiyuan Fang, Ryan Bucktrout, Yuchen Yang, Qianqian Ye, Zhen Shi, Taiyu Shen, Xinghui Wang, Zhicheng Peng, Chenxu Zhao, Bin Lv, Dongmei Xing, Yiwei Zhu, Xiaobing Li, Xinwei Li. Journal of dairy science. 2018 Dec;101:11175-11185. [Full Text Article] [PubMed:30316604]

Modelling disease risk for amyloid A (AA) amyloidosis in non-human primates using machine learning. Eric T Leung, Michael J Raboin, Jessica McKelvey, Adam Graham, Anne Lewis, Kamm Prongay, Aaron M Cohen, Amanda Vinson. Amyloid : the international journal of experimental and clinical investigation. 2019 Sep;;26:139-147. [Full Text Article] [PubMed:31210531] [PMC:PMC6667354]

Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]

Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]

Amyloidosis enhancing activity of bovine amyloid A fibrils in C3H/HeN mice and cynomolgus monkeys (Macaca fascicularis). Satomi Tsukawaki, Tomoaki Murakami, Kanata Ibi, Takeshi Kuraishi, Shosaku Hattori, Chieko Kai, Kazuhiko Suzuki, Tokuma Yanai. Journal of medical primatology. 2016 June;45:112-7. [Full Text Article] [PubMed:27072531] Related Antibodies: LS-B2130.

Serum amyloid A 1 induces suppressive neutrophils through the Toll-like receptor 2-mediated signaling pathway to promote progression of breast cancer. Xingjian Niu, Lei Yin, Xudong Yang, Yue Yang, Yucui Gu, Yutian Sun, Ming Yang, Yiran Wang, Qingyuan Zhang, Hongfei Ji. Cancer science. 2022 April;113:1140-1153. [Full Text Article] [PubMed:35102665] [PMC:PMC8990718]

Failure of heterogeneous amyloid-enhancing factor in geriatric squirrel monkeys (Saimiri boliviensis). Murakami T, Ibi K, Kuraishi T, Hattori S, Kai C, Ishiguro N, Yanai T. Journal of medical primatology. Dec;43:488-91. [Full Text Article] [PubMed:25041324] Related Antibodies: LS-B2130.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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