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S100B / S100 Beta

S100 calcium binding protein B

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Gene Name: S100 calcium binding protein B
Synonyms: S100B, NEF, Protein S100-B, S100, S100 calcium binding protein B, S100 calcium-binding protein B, S100beta, S-100 protein beta chain, S-100 protein subunit beta, S100-B
Target Sequences: NM_006272 NP_006263.1 P04271

Publications (3)

1
Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model. Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M,. PloS one. 2017 12:e0185989. (WB; Human) [Full Text Article] [PubMed:29028815]
2
The astrocytic response to the dopaminergic denervation of the striatum. Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M. Journal of neurochemistry. 2016 October;139:81-95. [Full Text Article] [PubMed:27230040]
3
Neuroglial transmitophagy and Parkinson's disease. Ingrid Morales, Alberto Sanchez, Ricardo Puertas-Avendaño, Clara Rodriguez-Sabate, Adrian Perez-Barreto, Manuel Rodriguez. Glia. 2020 November;68:2277-2299. [Full Text Article] [PubMed:32415886]

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Products
Antibodies (158)
Primary (158)
S100B / S100 Beta (158)
Human (111)
Mouse (53)
Rat (41)
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Cat (2)
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IHC (29)
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rabbit (84)
mouse (70)
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IgG (57)
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monoclonal mc (70)
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244 (1)
30 (1)
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OTI2H7 (2)
OTI3G6 (2)
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PS1B1-1 (3)
rS100B/1012 (2)
S100B/1012 (3)
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No (158)
S100B / S100 Beta Antibody - Anti-S100B / S100 antibody IHC staining of human nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer Pathology
Cancer
S100B / S100 Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$460
S100B / S100 Beta Antibody - Anti-S100B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Cancer Pathology
Cancer
S100B / S100 Beta Mouse anti-Human Monoclonal (9A11B9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$615
S100B / S100 Beta Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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S100B / S100 Beta Mouse anti-Bovine Monoclonal (SA-12) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µg/$460
S100B / S100 Beta Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
S100B / S100 Beta Goat anti-Human Polyclonal (Internal Region) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
S100B / S100 Beta Antibody - Immunochemical staining of human S100B in human lymphoma with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.
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S100B / S100 Beta Rabbit anti-Human Monoclonal (Preservative Free) (244) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
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S100B / S100 Beta Mouse anti-Human Monoclonal (Preservative Free) (1G8-C10-H8-B8) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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S100B / S100 Beta Mouse anti-Human Monoclonal (Preservative Free) (Biotin) (1G8-C10-H8-B8) Antibody
Human
ELISA
Biotin Conjugated, Preservative Free
50 µg/$343
S100B / S100 Beta Antibody - Western blot of recombinant S100B / S100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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S100B / S100 Beta Mouse anti-Human Monoclonal (aa1-92) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$323; 200 µl/$372; 500 µl/$533; 1 ml/$620; 2 ml/$853; 5 ml/$1,411
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S100B / S100 Beta Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
S100B / S100 Beta Antibody - Anti-S100B / S100 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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S100B / S100 Beta Rabbit anti-Human Polyclonal (aa28-56) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
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S100B / S100 Beta Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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S100B / S100 Beta Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
IHC, WB
FITC Conjugated
200 µl/$952
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S100B / S100 Beta Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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S100B / S100 Beta Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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S100B / S100 Beta Mouse anti-Bovine Monoclonal (SH-B1) Antibody
Rabbit, Bovine, Rat, Pig, Cat, Human
IHC, IHC-P
Unconjugated
0.1 ml/$275; 0.5 ml/$427; 1 ml/$571
S100B / S100 Beta Antibody - IHC testing of FFPE human schwanoma with S100 beta antibody (clone S100B/1012). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min followed by cooling at RT for 20 min.
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S100B / S100 Beta Mouse anti-Human Monoclonal (S100B/1012) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
S100B / S100 Beta Antibody - IHC testing of FFPE human schwanoma with S100 beta antibody (clone S100B/1012). Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min followed by cooling at RT for 20 min.
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S100B / S100 Beta Mouse anti-Human Monoclonal (Azide-free, BSA-free) (S100B/1012) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
S100B / S100 Beta Antibody - Formalin-fixed, paraffin-embedded human melanoma stained with S-100 antibody.
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S100B / S100 Beta Mouse anti-Bovine Monoclonal (4C4.9) Antibody
Mouse, Bovine, Rat, Human
IHC
Unconjugated
0.1 ml/$275; 0.5 ml/$360; 1 ml/$459
S100B / S100 Beta Antibody - Western blot testing of S100 beta antibody and Lane 1: rat brain; 2: rat brain; 3: MCF-7; 4: HeLa; 5: SMMC-7721; 6: Jurkat; 7: COLO320 cell lysate
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S100B / S100 Beta Rabbit anti-Human Polyclonal (aa64-78) Antibody
Rabbit, Mouse, Goat, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human
WB
Unconjugated
100 µg/$575
S100B / S100 Beta Antibody - Immunochemical staining of human S100B in human cerebellum with rabbit monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
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S100B / S100 Beta Rabbit anti-Human Monoclonal (Preservative Free) (034) Antibody
Human
IHC-P
Unconjugated, Preservative Free
100 µl/$412
S100B / S100 Beta Antibody - Western blot of recombinant S100B / S100.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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S100B / S100 Beta Rabbit anti-Mouse Polyclonal (aa1-92) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$329; 200 µl/$379; 500 µl/$547; 1 ml/$649; 2 ml/$884; 5 ml/$1,475
S100B / S100 Beta Antibody - IHC testing of human melanoma stained with S100B antibody + AEC chromogen (clone 4C4.9). No special pretreatment is required for IHC staining of formalin-paraffin tissues.
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S100B / S100 Beta Mouse anti-Human Monoclonal (4C4.9) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
S100B / S100 Beta Antibody - IHC testing of human melanoma stained with S100B antibody + AEC chromogen (clone 4C4.9). No special pretreatment is required for IHC staining of formalin-paraffin tissues.
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S100B / S100 Beta Mouse anti-Human Monoclonal (Azide-free, BSA-free) (4C4.9) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
Select
S100B / S100 Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
S100B / S100 Beta Antibody - Immunochemical staining of human S100B in human lymphoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Select
S100B / S100 Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC-P
Unconjugated
50 µl/$317; 100 µl/$375; 200 µl/$473
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).