S100A9 / MRP14

S100 calcium binding protein A9

S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

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Products

Proteins (25)

Type

Over-Expression Lysate (2)

Recombinant (23)

Target

S100A9 / MRP14 (25)

Publications

No (25)

Tag

10His-B2M, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

6His-SUMO, N-terminus (1)

6His-SUMO, N-terminus + Myc, C-terminus (1)

GST (1)

His (8)

His, N-Terminal (1)

His, N-terminus (2)

His, N-terminus + His, C-terminus (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (3)

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Species

Bovine (1)

Cow (2)

Human (13)

Mouse (5)

Rat (3)

Source

293T Cells (1)

Baculovirus (1)

E. coli (19)

HEK 293 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (4)

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Mouse S100A9 / MRP14 Protein (Recombinant His) - LS-G3612

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human S100A9 / MRP14 Protein (Recombinant His) - LS-G772

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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Human S100A9 / MRP14 Protein (Recombinant) (Thr2-Pro114) - LS-G39193

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

13.2kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Human S100A9 / MRP14 Protein (Recombinant GST) (Full Length) - LS-G30304

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

38.28 kDa

Price:

10 µg/$479; 25 µg/$670

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Cow S100A9 / MRP14 Protein (Recombinant 6His-SUMO, N-terminus + Myc, C-terminus) (aa2-156) - LS-G56507

Source:

E. coli

Tag:

6His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Cow S100A9 / MRP14 Protein (Recombinant 10His-B2M, N-terminus + Myc, C-terminus) (aa2-156) - LS-G56508

Source:

E. coli

Tag:

10His-B2M, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human S100A9 / MRP14 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65137

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.1 kDa

Price:

20 µg/$1,107

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Human S100A9 / MRP14 Protein (Recombinant) (Met1-Pro114) - LS-G97855

Source:

E. coli

Tag:

None

Molecular Weight:

26 and 13 kDa

Price:

100 µg/$843

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Human S100A9 / MRP14 Protein (Recombinant His) (Met1-Pro114) - LS-G97857

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.6 kDa

Price:

100 µg/$721

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Mouse S100A9 / MRP14 Protein (Recombinant His) (Aal2-Lys113) - LS-G98257

Source:

E. coli

Tag:

His

Molecular Weight:

15 kDa

Price:

100 µg/$721

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S100A9 / MRP14 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99922

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.1 kDa

Price:

100 µg/$494

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Human S100A9 / MRP14 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74932

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.1 kDa

Price:

20 µg/$150

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Human S100A9 / MRP14 Protein (Recombinant His) (aa32-114) - LS-G141171

Source:

E. coli

Sequence Length:

82 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

9.13 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human S100A9 / MRP14 Protein (Recombinant His, N-Terminal) - LS-G142325

Source:

Sf9 Cells

Tag:

His, N-Terminal

Molecular Weight:

13 kDa

Price:

20 µg/$677

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Human S100A9 / MRP14 Protein (Recombinant His, N-terminus) - LS-G145973

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

13.24 kDa

Price:

20 µg/$270; 100 µg/$390

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Rat S100A9 / MRP14 Protein (Recombinant His, N-terminus) - LS-G146354

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

13.01 kDa

Price:

20 µg/$270; 100 µg/$390

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Mouse S100A9 / MRP14 Protein (Recombinant His, N-terminus + His, C-terminus) - LS-G146474

Source:

E. coli

Tag:

His, N-terminus + His, C-terminus

Molecular Weight:

14.3kDa

Price:

20 µg/$270; 100 µg/$390

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Human S100A9 / MRP14 Protein (Recombinant) (Thr2-Pro114) - LS-G138639

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

13.2 kDa

Price:

10 µg/$248; 50 µg/$288

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Mouse S100A9 / MRP14 Protein (Recombinant His-SUMO) (Full Length) - LS-G21157

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

28.9 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Bovine S100A9 / MRP14 Protein (Recombinant His-T7) (aa12-89) - LS-G24496

Source:

E. coli

Tag:

His-T7

Molecular Weight:

12.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human S100A9 / MRP14 Protein (Recombinant 6His, N-terminus) (Thr2-Pro114) - LS-G26620

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

15 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365; 250 µg/$518

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Rat S100A9 / MRP14 Protein (Recombinant 6His-SUMO, N-terminus) (aa2-113) - LS-G56510

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human S100A9 / MRP14 Protein (Recombinant His) (aa1-114) - LS-G14277

Source:

E. coli

Tag:

His

Molecular Weight:

14.5 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Rat S100A9 / MRP14 Protein (Recombinant His) (aa1-113) - LS-G14278

Source:

E. coli

Tag:

His

Molecular Weight:

14.4 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Mouse S100A9 / MRP14 Protein (Recombinant His) (aa1-113) - LS-G14279

Source:

E. coli

Tag:

His

Molecular Weight:

14.3 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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