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RYK

receptor-like tyrosine kinase

RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: receptor-like tyrosine kinase
Family/Subfamily: Protein Kinase , RYK
Synonyms: RYK, D3S3195, Hydroxyaryl-protein kinase, JTK5, JTK5A protein tyrosine kinase, RYK1, Vik, Tyrosine-protein kinase RYK, Receptor-like tyrosine kinase, JTK5A, Tyrosine kinase ryk
Target Sequences: NM_002958 NP_002949.2 P34925

Publications (1)

1
The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:5840-8. [PubMed:16723543] Related Antibodies: LS-C99132.

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Products
Proteins (11)
Over-Expression Lysate (5)
Recombinant (6)
RYK (11)
No (11)
DDK (Flag)-His, C-terminus (1)
GST, N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (7)
Human (9)
Mouse (1)
293T Cells (3)
E. coli (2)
HEK 293 Cells (5)
Wheat Germ Extract (1)
RYK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.6 kDa
100 µg/$710
RYK Protein - Recombinant  Related To Receptor Tyrosine Kinase By SDS-PAGE
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E. coli
His-T7
33.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
RYK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67.9 kDa
100 µg/$710
RYK Protein - Purified recombinant protein RYK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
67.6 kDa
20 µg/$1,107
RYK Protein - Purified recombinant protein RYK was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
67.9 kDa
20 µg/$1,107
RYK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
67.9 kDa
20 µg/$215
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293T Cells
Myc-DDK (Flag)
67.9 kDa
20 µg/$150
RYK Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
67.6 kDa
20 µg/$215
RYK Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
RYK Protein - Recombinant Related To Receptor Tyrosine Kinase By SDS-PAGE
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E. coli
His-T7
32.1 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
RYK Protein
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HEK 293 Cells
DDK (Flag)-His, C-terminus
25 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).