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RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | runt-related transcription factor 3 |
Synonyms: | RUNX3, Acute myeloid leukemia gene 2, CBF-alpha-3, PEA2 alpha C, PEBP2 alpha C, PEBP2-alpha C, PEBP2A3, PEBP2aC, AML2, Oncogene AML-2, CBFA3, PEA2-alpha C, Transcription factor AML2 |
Target Sequences: | NM_004350 NP_004341.1 Q13761 |
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