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RTN4 / Nogo

reticulon 4

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

Gene Name: reticulon 4
Family/Subfamily: Reticulon
Synonyms: RTN4, Human NogoA, My043 protein, Neurite outgrowth inhibitor, NOGOC, NSP-CL, Nogo protein, KIAA0886, Reticulon 5, Reticulon-4, Reticulon-5, Reticulon 4, RTN4-B1, RTN-X, RTN4-A, RTN4-B2, RTN4-C, Nbla00271, Neurite growth inhibitor 220, NI220/250, NOGO-A, Nogo-C, ASY, Foocen, Nbla10545, NOGO, Nogo-B, NSP
Target Sequences: NM_020532 NP_065393.1 Q9NQC3

Publications (1)

1
Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination. Sissy Kalayil, Sagar Bhogaraju, Florian Bonn, Donghyuk Shin, Yaobin Liu, Ninghai Gan, Jérôme Basquin, Paolo Grumati, Zhao-Qing Luo, Ivan Dikic. Nature. 2018 May;557:734-738. [Full Text Article] [PubMed:29795347] [PMC:PMC5980784] Related Antibodies: LS-B6516.

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ELISA Kits (13)
Custom (3)
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Sandwich CLIA (1)
RTN4 / Nogo (13)
Human (6)
Mouse (2)
Rat (5)
96-Well Microplate (3)
96-Well Strip Plate (10)
No (13)
Cell Culture Supernatants (1)
Cell Lysates (1)
Cell Supernatant (1)
Plasma (8)
Serum (8)
Tissue Homogenates (4)
RTN4 / Nogo ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
RTN4 / Nogo ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
RTN4 / Nogo ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
RTN4 / Nogo ELISA Kit
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Custom
96-Well Strip Plate
Mouse
1 Plate/$669
RTN4 / Nogo ELISA Kit
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Custom
96-Well Microplate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$823
RTN4 / Nogo ELISA Kit
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Sandwich
96-Well Microplate
Human
0.42 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants
1 Plate/$610
RTN4 / Nogo ELISA Kit
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Custom
96-Well Strip Plate
Human
1 Plate/$669
RTN4 / Nogo ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
RTN4 / Nogo ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
RTN4 / Nogo ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Chemiluminescent
Cell Supernatant, Plasma, Serum
1 Plate/$669
RTN4 / Nogo ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
RTN4 / Nogo ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
RTN4 / Nogo ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).