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Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Gene Name: | Ras-related GTP binding A |
Synonyms: | RRAGA, FIP-1, FIP1, RAGA, Ras-related GTP binding A, Rag A |
Target Sequences: | NM_006570 NP_006561.1 Q7L523 |
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