RPRD1B

Regulation of nuclear pre-mRNA domain containing 1B

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RPRD1B (5)

Publications

No (5)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human RPRD1B Protein (Recombinant His) - LS-G3261

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human RPRD1B Protein (Recombinant GST) (Full Length) - LS-G34827

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RPRD1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87264

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.7 kDa

Price:

20 µg/$150

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Human RPRD1B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70501

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.7 kDa

Price:

20 µg/$1,107

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RPRD1B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110704

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.7 kDa

Price:

100 µg/$494

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